Local cells reorganization

Studies of Lsc in neutrophils also suggest that localization may play a role in activation of Rho (Francis et al., 2006). Immunostaining showed that Lsc was largely distributed uniformly on the plasma membrane. After 5 min of stimulation with W-formyl-methionyl-leucyl-phenylalanine (fMLP), the Lsc became enriched in the leading and trailing edges of the cells, sites of active cytoskeletal reorganization in these stimulated cells. While simple translocation to the plasma membranes does not appear to be a viable mechanism for activation in this case, localization within the membrane to direct activity to specific sites is indicated. 

The phenotype of differentiated Thl and Th2 cells is stabilized after about 3-5 divisions [14]. Early in the differentiation, 114 and IFNy loci are easily accessible 114 and IFNy genes are localized away from the silenced centromeric chromatin. Conversely, in Thl cells, 52% of 114 alleles are reorganized in apposition to centromeric heterochromatin and in Th2 cells 67% of IFN-y alleles are directed to heterochromatic domains, which... 

Hyaluronan is involved in many biological processes and is present in almost all body tissues of vertebrates where it plays a role in the regulation of cellular activities. It speeds up (or slows) cell division, inflnences migration, and is involved in the reorganization of chromatin sbucture and gene switching. Hyaluronan is localized in the nucleus, the cytoplasm... 

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