Liver microscopic anatomy

H. D. Schmidt, On the Microscopic Anatomy, Physiology, and Pathology of the Human Liver, Confederate Medical and Surgical Journal 1 (1864) 49-54, 65-... 

Connective tissue It appears that I Waleus (1640) was the first to describe connective tissue in the liver, namely in the area surrounding the vessels. M. Malpighi (who is considered the founder of microscopic anatomy) detected connective tissue between the acini in 1666. 

The diverse metabolic activities of the liver make it susceptible to solvent induced in-jiuy, particularly from reactive intermediates which damage cellular macromolecules. The microscopic anatomy of the liver provides an explanation for this susceptibility. The basic unit of the liver is the hepatic lobule which consists of a central vein surrounded radially by sinusoids of liver cells (hepatocytes). Portal triads consisting of a hepatic artery, a hepatic vein and a bile canniliculus are located at the periphery. Liver cells closest to the vascular... 

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