Liquid sterilization

Liquid sterilants are known to corrode the metal parts of articles and instmments that are to be sterilized, although articles composed exclusively of glass or certain type of corrosion-resistant metal alloys can be safely processed. Because the degree of corrosion is related to length of exposure, many articles are merely disinfected in a shorter exposure time. Disinfection may be suitable for certain appHcations. The safety of using Hquid sterilants must be judged by a qualified microbiologist. 

Processing in Hquid sterilants results in wet products which require highly specialized packaging. Therefore, Hquid sterilization should only be considered if the sterilized article is to be used almost immediately. Liquid sterilants or their residues can be harmful to living tissues. Therefore it is always necessary to rinse articles with sterile water or saline solution foUowing treatment. Whereas Hquid sterilization is an extremely useful method for articles that caimot withstand the conditions of steam sterilization, the problems associated with its use limit its appHcation. 

Veyre, R. 1985a. Ultrafiltration mineral membranes for liquid sterilization. Inf. Chim. 261 187-91. 

Skowronski et al. (1985) administered Alcide (a liquid sterilizer consisting of sodium chlorite and lactic acid that form chlorine dioxide) to mice and rats in gavage doses of 1 and 0.1 mL, respectively, on gestation days 6-15. No signs of maternal toxicity were observed, and there were no statistically significant adverse fetal effects. 

The mam characteristic properties of asbestos fibers that can be exploited in industrial applications arc their thermal, electrical, and sound insulation nonflammability matrix leinfoicement (cement, plastic, and resins) adsorption capacity (filtration, liquid sterilization) wear and friction properties (friction materials) and chemical inertia (except in acids). These properties have led to several main classes of industrial products or applications fire protection and heat or sound insulation,... 

Table 3 Checklist on Process Evaluation Leading to Optimization and Validation of a Liquid Sterile Dosage Form... 

In all fermentation processes, it is necessary to have contamination-free fermentation media and seed cultures. Liquid sterilization of the fermentation medium is conducted by two means.1011 Contaminating microorganisms can be removed from fluids by filtration. With improvements in membrane technology, sterile filtration is finding wider use, but can only be used with completely soluble media. 

Route of administration Type of non-Aqueous liquids -sterile dosage form Non-aqueous fluids Solid dosage forms... 

Other chemicals used historically as liquid sterilants include a solution based on hydrogen peroxide (qv). This was once offered commercially. 

Paraffin liquid sterile solution Dipping bath for sutures... 

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