Lipoxygenase induction

It is possible that dietary flavonoids participate in the regulation of cellular function independent of their antioxidant properties. Other non-antioxidant direct effects reported include inhibition of prooxidant enzymes (xanthine oxidase, NAD(P)H oxidase, lipoxygenases), induction of antioxidant enzymes (superoxide dismutase, gluthathione peroxidase, glutathione S-transferase), and inhibition of redox-sensitive transcription factors. 

Williams, JH and Bliss, TV (1989) An in vitro study of the effect of lipoxygenase and cyclooxygenase inhibitors of arachidonic acid on the induction and maintenance of long-term potentiation in the hippocampus. Neurosci. Lett. 107 301-309. 

Lipoxygenases catalyse the regio-specific and stereoselective oxygenation of unsaturated fatty acids. The mammalian enzymes have been detected in human platelets, lung, kidney, testes and white blood cells. The leukotrienes, derived from the enzymatic action of the enzyme on arachidonic acid, have effects on neutrophil migration and aggregation, release of lysosomal enzymes, capillary permeability, induction of pain and smooth muscle contraction (Salmon, 1986). 

Yeadon, M., Eve, D. and Payne, A.N. (1993c). Induction of airway hyperresponsiveness increases the potency of BW B70C, a 5-lipoxygenase inhibitor, to prevent allergic bron-choconstriction in sensitised guinea-pigs. Br. J. Pharmacol. 108, 186P. 

J. F.G. 1993. Kinetic analysis of the induction period in lipoxygenase catalysis. Biochemistry 32 7686-7691. 

Beierschmitt, W. P, McNeish, J. D., Griffiths, 1C J., Nagahisa, A., Nakane, M. and Amacher, D. E. (2001) Induction of hepatic microsomal drug-metabolizing enzymes by inhibitors of 5-lipoxygenase (5-LO) studies in rats and 5-LO knockout mice. Toxicol Sci 63,15-21. 

Promotion of flowering (by irradiation during the night) in Chenopodium, Hordeum, Hyoscyamus Inhibition of flowering (by irradiation during the night) mLemna,Pharbitis, Xanthium Development of primary leaves and formation of leaf primordia in Sinapis Enzyme induction (phenylalanin-ammonialyase ascorbate oxidase) and repression (lipoxygenase) in Sinapis... 

Kelavkar UP, Cohen C, Kamitani H, Eling TE, Badr KF. Concordant induction of 15-lipoxygenase-1 and mutant p53 expression in human prostate adenocarcinoma correlation with Gleason staging. Carcinogenesis. 21 (2000) 1777-1787. 

Pidgeon GP, Kandouz M, Meram A, Honn KV. Mechanisms controlling cell cycle arrest and induction of apoptosis after 12-lipoxygenase inhibition in prostate cancer cells. Cancer Res. 62 (2002) 2721-2727. 

---