Lipoproteins apolipoproteins

Apolipoproteins The apolipoproteins associated with lipoprotein particles have a number of diverse functions, such as providing recognition sites for cell-surface receptors, and serving as activators or coenzymes for enzymes involved in lipoprotein metabolism. Some of the apolipoproteins are required as essential structural components of the particles and cannot be removed (in fact, the particles cannot be produced without them), whereas others are transfered freely between lipoproteins. Apolipoproteins are divided by structure and function into five major classes, A through E, with most classes having subclasses, for example, apo A-l and apo C-ll. [Note Functions of all of the apolipoproteins are not yet known.]... 

PLASMA LIPOPROTEINS, APOLIPOPROTEINS, AND PROTEINS CONCERNED WITH LIPID METABOLISM... 

In this article we shall review recent advances in plasma lipoproteins, apolipoproteins, and those proteins concerned with lipoprotein lipid metabolism. This is a rapidly growing field, far too large to enable all aspects to be covered in a single paper. In order to keep to a manageable size, we shall focus on areas in which there have been recent major advances. Our treatment of other areas will be brief, as adequate reviews are in most cases available. Clinical details of primary disorders of plasma lipid metabolism are very well covered in a series of reviews in The Metabolic Basis of Inherited Disease (5th Ed., J. B. Stanbury, J. B. Wyngaarden, D. S. Fredrickson, J. L. Goldstein, and M. S. Brown, eds.) (B52, G13, G20, H24, N8, S3, S56). Disordered lipid metabolism, and especially secondary disorders of lipid metabolism, are equally well covered in Metabolic Control and Disease (8th Ed., P. K. Bondy and L. E. Rosenberg, eds.) (H16). 

K9. Kashyap, M. L., Srivastava, L. S., Hynd, B. A., Gartside, P. S., and Perisutti, G., Quantitation of human apolipoprotein G-III and its subspecies by radioimmunoassay and analytical isoelectric focusing Abnormal plasma triglyceride-rich lipoprotein apolipoprotein C-III subspecie concentrations in hypertriglyceridemia. J. Lipid Res. 22, 800—810 (1981). 

Ul. Utermann, G., Isolation and partial characterization of an arginine-rich apolipoprotein from human plasma very-low-density lipoproteins Apolipoprotein E. Hoppe Seylers Z. Physiol. Chem. 356, 1113-1121 (1975). 

Z2. Zannis, V. I., and Breslow, J. L., Human very low density lipoprotein apolipoprotein E isoprotein polymorphism is explained by genetic variation and posttranslational modification. Biochemistry 20, 1033-1041 (1981). 

Lipids, Lipoproteins, Apolipoproteins, and Other Cardiovascular Risk Factors... 

Cortner JA, Coates PM, Bennett MJ, Cryer DR, Le NA. Familial combined hyperlipidaemia use of stable isotopes to demonstrate overproduction of very low-density lipoprotein apolipoprotein B by the liver. J Inherit Metab Dis 1991 14 915-22. 

Mahley RW, Innerarity TL, Rail SC, Jr., Weisgraber KH. Plasma lipoproteins apolipoprotein structure and function. J Lipid Res 1984 25 1277-94. 

Schaefer EJ, Blum CB, Levy RI, Jenkins LL, Alaupovic P, Foster DM, Brewer HB, Jr. Metabolism of high-density lipoprotein apolipoproteins in Tangier disease. N Engl J Med 1978 299 905-10. 

Lipids, Lipoproteins, Apolipoproteins, and Other Cardiovascular Risk Factors Lipids, Lipoproteins, Apolipoproteins, and Other Cardiovascular Risk Factors Appendix... 

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