Lipid and lipoprotein metabolism

Nicotinic acid is used in the treatment of hyperlipidemia. It causes various changes in lipid and lipoprotein metabolism when administered in high doses (up to 5 g/d) ... 

Staels s. Dallongeville J, Auwerx J, Schoonjans K, Leitersdorf E, Fru-chart J. Mechanism of action of fibrates on lipid and lipoprotein metabolism. Circulation 1998 98 2088-2093. 

H3. Hamilton, R. L., Hepatic secretion and metabolism of high density lipoproteins. In Disturbances in Lipid and Lipoprotein Metabolism (J. M. Dietschy, A. M. Gotto, Jr., and J. A. Ontko, eds.), pp. 155-171. Clinical Physiology Series. American Physiological Society, Washington, D.C., 1978. 

The liver is central to both lipid and lipoprotein metabolism and homeostasis. There are three major plasma lipids cholesterol, phospholipids and triglycerides. All are highly insoluble in water. 

The authors gratefully acknowledge the contribution by Drs, John Albers and Paul Bachorik on which portions of this chapter are based. Additional portions have been adapted from Rifai N, Kwiterovich PO Jr. Disorders of lipid and lipoprotein metabolism in children and adolescents. In Soldin SJ, Rifai N, Hick JMB eds. Biochemical basis of pediatric diseases, 3rd ed. Washington DC AACC Press, 1998. 

TR, VDR and RAR are targets for current medicines. PPARs are lipid-activated transcription factors that regulate the expression of genes involved in the control of lipid and lipoprotein metabolism, glucose homeostasis and... 

Bocher, V., Pineda-Torra, I., Fruchart, J. C., and Staels, B. (2002). PPARs Transcription factors controlling lipid and lipoprotein metabolism. Ann NY Acad Sci 967, 7-18. 

FIGURE 9.1 Simplified overview of lipid and lipoprotein metabolism with some key enzymes numbered (1) cholesteryl ester transfer protein (CETP), (2) hepatic triglyceride lipase, (3) lecithin cholesterol acyl transferase (LCAT), and (4) lipoprotein lipase. 

Bauer, J. 1996. Comparative lipid and lipoprotein metabolism. Veterinary Clinical Pathology 25 49-56. 

Liver is a central organ affecting lipid and lipoprotein metabolism. Dietary CLA has been reported to increase hepatic lipid contents in mice, concomitant with a decrease in body fat mass (6-8), although it is not clear whether this is the case for other experimental animals and humans. Hence,... 

Wong, S.H.,Nestel, RJ., Trimble, R.P., Stores, G.B., lllman, R.J. Topping, D.L 1984. Biochim. Biophys. Acta 792 103-109. The adaptive effects of dietary fish and safflower oil on lipid and lipoprotein metabolism in perfused rat liver. 

The mechanism of action of thyroid hormone upon lipid and lipoprotein metabolism is not established. Olson and Vester (1960) have reviewed the literature on the subject. Only recent developments will... 

Nonetheless, the debate over what constitutes the "ideal" fat is controversial, since it uses the term saturated fat without distinguishing individual SFA. In this sense, even a cursory analysis of some of the so-called saturated fats (e.g., palm oil, lard, tallow, butter, coconut oil) reveals that they have distinct profiles and empirically exert different metabolic effects. Accordingly, research in recent years has shifted toward elucidating the effects of specific dietary fatty acids in TAG, as opposed to specific classes of fats, on plasma lipids and lipoprotein metabolism [141]. 

Mahley RW (1978) Alterations in plasma lipoproteins induced by cholesterol feeding in animals including man. In Dietschy JM, Gotto AM, Outko JH (eds) Disturbances in lipid and lipoprotein metabolism. Am Physiol Soc, Bethesda, pp 181-197... 

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