Lipogenic genes

Jump DB et al Coordinate regulation of glycolytic and lipogenic gene expression by polyunsaturated fatty acids. J Lipid Res... 

Docosahexaenoic acid (DHA) is a long-chain highly unsaturated fatty acid that is abundant in fish oil and is a precursor of several eicosanoids. DHA has a lipid-lowering effect through the suppression of lipogenic gene expression in the liver of rodents (Ikeda et al., 1998 Park and Harris, 2003 Buckley et al., 2004). In this paper, we introduce the evaluation of the physiological function of DHA in diet-induced lipodystrophy model mice. 

Spiegelman BM, Ginty CA (1983) Fibronectin modulation of cell shape and lipogenic gene expression in 3T3-adipocytes. Cell 35(3 Pt 2) 657-666... 

Xu, J., Nakamura, M. T., Cho, H. P., and Clarke, S. D. Sterol regulatory element binding protein-1 expression is suppressed by dietary polyunsaturated fatty acids. A mechanism for the coordinate suppression of lipogenic genes by polyunsaturated fats. J Biol Chem 274 (1999b) 23577-23583. 

Yahagi, N., Shimano, H., Hasty, A. H., Amemiya-Kudo, M., Okazaki, H., Tamura, Y., lizuka, Y., Shionoiri, F., Ohashi, K., Osuga, J., et al. A crucial role of sterol regulatory element-binding protein-1 in the regulation of lipogenic gene expression by polyunsaturated fatty acids. J Biol Chem 274 (1999) 35840-35844. 

Zhang, W., Patil, S., Chauhan, B., Guo, S., Powell, D. R., Le, J., Klotsas, A., Matika, R., Xiao, X., Franks, R., et al. FoxOl regulates multiple metabolic pathways in the liver effects on gluconeogenic, glycolytic, and lipogenic gene expression. J Biol Chem 281 (2006) 10105-10117. 

Foretz, M., Pacot, C., Dugail, I., Lemarchand, P., Guichard, C., Le Liepvre, X., Berthelier-Lubrano, C., Spiegelman, B., Kim, J.B., Ferre, P. and Foufelle, F. ADDl/SREBP-lc is required in the activation of hepatic lipogenic gene expression by glucose. Mol Cell Biol, 19 (1999) 3760-3768. 

Suppression of lipogenic gene expression by polyunsaturated fatty acids... 

Fig. 12. Panel A Inhibitory effects of various polyunsaturated fatty acids (PUFA) on sterol regulatory element binding protein (SREBP)-lc promoter activity. EtOH, ethanol SA, saturated fatty acid OL, oleic acid LA, linoleic acid DHA, docosa-hexaenoic acid EPA, eicosapentaenoic acid AA, arachidonic acid. Panel B Mechanism by which polyunsaturated fatty acids suppress the SREBP-1 c promoter activity, through an effect on the liver X receptor (LXR)/9-c/s-retinoic acid receptor (RXR) activation pathway [redrawn from Yoshikawa etal. (129), reproduced with permission]. PUFA competitively interfere with binding of the endogenous ligand (possibly oxysterols) to LXR, thereby repressing LXR/RXR transactivity and SREBP-lc and lipogenic gene expression. Meanwhile, PUFA can bind and activate peroxisome proliferator activated receptor-a (PPARa) to induce 3-oxidation of fatty acids. PPRE PPAR response element LXRE LXR response element.

Y (37), we speculate that the relative potency of activation of a vs. Y could be responsible for the different actions of these isomers. These results demonstrate that the hypolipidemic effect of CLA can be attributed to the effect of the 10f,12c-CLA isomer. In addition, it is possible that the flO,cl2-CLA isomer enhanced CPT activity and reduced FAS activity through its action at the transcriptional levels of these lipogenic genes. 

Peterson, D.G., Matitashvih, E.A., and Bauman, D.E. (2002) Diet-Induced Milk Fat Depression in Dairy Cows Is Characterized by Increased Milk Fat Content of flO, cl2 CLA and Corresponding Reductions in Lipogenic Gene Expression, FASEB J. 16, A232 (Abstr.). 

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