Lipidomics cancer

More and more lines of evidence support a rationale that lipids are associated with many human diseases (e.g., diabetes and obesity, atherosclerosis and stroke, cancer, psychiatric disorders, neurodegenerative diseases and neurological disorders, and infectious diseases) (see Chapter 17). Therefore, the research on lipids has become a unique new discipline called lipidomics nowadays. 

Doria, M.L., Cotrim, Z., Macedo, B., Simoes, C., Domingues, P., Helguero, L. and Domingues, M.R. (2012) Lipidomic approach to identify patterns in phospholipid profiles and define class differences in mammary epithelial and breast cancer cells. Breast Cancer Res. Treat. 133, 635-648. 

Kiebish, M.A., Han, X., Cheng, H., Chuang, J.H. and Seyfried, T.N. (2008) Cardiolipin and electron transport chain abnormalities in mouse brain tumor mitochondria Lipidomic evidence supporting the Warburg theory of cancer. J. Lipid Res. 49, 2545-2556. 

Millon et al. monitored plaque inflammation in atherosclerotic rabbits using a combined PET/MR scanner. Proton magnetic resonance metabolomic characterization of ovarian serous carcinoma was performed by Vettukattil et for diagnostic purposes. Pan et using NMR lipidomic approach, noticed increased unsaturation of lipids in cytoplasmic lipid droplets in DAOY cancer cells in response to cisplatin treatment. Akoudad et examined formation of cerebral microbleeds associated with the progression of ischemic vascular lesions, while Kos-tara et followed the progression of coronary heart disease NMR-based lipidomic analysis of blood lipoproteins. 

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