Transition, lipid phase

Discuss the effects on the lipid phase transition of pure dimyris-toyl phosphatidylcholine vesicles of added (a) divalent cations, (b) cholesterol, (c) distearoyl phosphatidylserine, (d) dioleoyl phosphatidylcholine, and (e) integral membrane proteins. 

Marsh, D. (1991). Analysis of the chainlength dependence of lipid phase transition temperatures main and pretransitions of phosphatidylcholines main and non-lamellar transitions of phosphatidylethanolamines, Biochem. Biophys. Acta-Biomembranes, 1062, 1-6. 

Elamrami, K. and Blume, A. (1983). Effect of lipid phase transition on the kinetics of H 1 /OH diffusion across phosphatidic acid bilayers, Biochim. Biophys. Acta, 727, 22-30. 

The quality of alignment in the oriented membrane samples was examined by P-NMR. Figure 4A shows that the lipids are well oriented at all temperatures above and below the lipid phase transition at Tm 23 °C. Any potential disturbance of the bilayer by the peptide was also examined by P-NMR, using a very high peptide lipid ratio of 1 10 in multilamellar vesicles. The charac-... 

LIPID PHASE TRANSITION KINETICS LIPID PHASE TRANSITION KINETICS LIPID TRACER KINETICS Lipid transfer across membrane bilayers, PHOSPHOLIPID FLIP-FLOP Lipoamide,... 

LIPID PHASE TRANSITION KINETICS Membrane lipid asymmetry,... 

Lipid phase transitions are often slow on the timescale accessible to simulations, such as the gel to liquid-crystalline phase transition. Using the MARTINI model, liquid-crystalline to gel phase transitions and domain formation have been... 

Lee, A.G. Lipid phase-transitions and phase-diagrams. 2. Mixtures involving lipids. Biochim. Biophys. Acta 1977, 472, 285-344. 

I assume there must be some temperature dependence of hapten binding. Is there any correlation (or absence of correlation) with solid-liquid lipid phase transitions (i.e., with membrane fluidity) ... 

Marsh, D. (1991). Analysis of the chain length dependence of lipid phase transition temper tacfeHn. 

Rehfeld, S.J., et al. 1988. Calorimetric and electron spin resonance examination of lipid phase transitions in human stratum corneum Molecular basis for normal cohesion and abnormal desquamation in recessive X-linked ichthyosis. J Invest Dermatol 91 499. 

Koynova R, MacDonald RC (2004) Columnar DNA superlattices in lamellar oethylpho-sphatidylcholine lipoplexes mechanism of the gel-liquid crystalline lipid phase transition. Nano Lett 4 1475-1479... 

Rourke, B.C. and Gibbs, A.G. (1999). Effects of lipid phase transitions on cuticular permeability model-membrane and in situ studies. J. Experim. Biol., 202, 3255-3262. 

The influence of substituent size, polarity, and location on the thermotropic properties of synthetic phosphatidylcholines has been studied by Menger et al. [18], The effect of increasing membrane curvature on the phase transition has been investigated by DSC and FTIR [19]. In addition, a data bank, LIPIDAT, on lipid phase transition temperatures and enthalpy changes is available [20, 21],... 

In addition, the reversibility of phase transition in lipid-water systems has been studied [30]. It was observed that the relaxation times in the transition region and the lifetimes of the metastable phases are similar, and sometimes significantly longer than the times characteristic of the biomembrane processes. The question arises as to the physiological significance of the equilibration that occurs a long time after lipid phase transition. 

Golden, G.M., Guzek, D.B., Kennedy, A.H., McKie, J.E., and Potts, R.O. Stratum corneum lipid phase transitions and water barrier properties. Biochemistry. 26 2382-2388 (1987). 

Mattai, J., Froebe, C.L., Rhein, L.D. et al. Prevention of model stratum corneum lipid phase transition in vitro by cosmetic additives-differential scanning calorimetry, optical microscopy, and water evaporation studies. J. Soc. Cosmet. Chem. 1993, 44 89-100. 

These alterations were assigned to lipid phase transitions. 

Quantitative investigation of recognition of this pair of liposomes was performed with isothermal titration microcalorimetry (ITC). It has been found that one-to-one binding between adenine and barbituric acid in the lipid/water/lipid interface occurs. However at T= 58°C, above the main lipid phase transition, the situation is different and no liposomal binding is detected. This is mainly due to the molecular disorder within the bilayer (liquid-disordered/liquid ordered phase coexistence) that limits the capacity of complementary moieties to bind, due to the weakening of the hydrogen bonds at these high temperatures. 

Analysis of the results and comparison with the lipid phase transition observed iq the bulk lipid/water systems allows to conclude that the lowest temperature during heating at which measurable diffusion occurred correlates with the onset of formation of the lamellar Ln liquid crystalline phase of the given phospholipid. Therefore, the data support a correlation between the surface and bulk phase transitions. This was confirmed in recent studies where the lipid surface phase transition was successfully measured for the first time in foam film by independent means involving the detailed investigations of the temperature dependences of the W(C) curve for the foam film and its thickness. 

Blok, M. C. et al. The effect of chain length and lipid phase transitions on the selective permeability properties of liposomes. Biochimica et Biophysica Acta 406 187-196, 1975. 

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