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Lipid intermediates, glycoprotein

Glycosyl transfer to hydrophobic acceptors by polyenzyme systems is a possibility. Transfer of sugar to endogenous lipid intermediates present in microsomal material from liver has been implied in the incorporation of glucose, mannose, and iV-acetylglucosamine into endogenous glycoprotein (A4, B6, B7, B8, D2, Mil, R7, T5). Dolichol monophosphate... [Pg.274]

The mechanism of synthesis of polysaccharides is a controversial issue. After discovery, by Cardini s group, that starch may be polymerized on a protein,152,153 it was suggested153 that all nascent, polysaccharide chains might be covalently associated with a protein. Connected with the formation of glycoprotein is the involvement of lipid intermediates. We shall analyze the biosynthetic pathways of polysaccharides where partial or complete evidence of this kind of mechanism has been educed. [Pg.360]

Glycoproteins Fonnd in Plants, Type of Linkage between the Peptide and Saccharide Moieties, and Involvement of Lipid Intermediates in Their Biosynthesis... [Pg.372]

Linkage type Source Glycoprotein Lipid intermediates References... [Pg.372]

Glaser, L. Lindsay, B. (1974) The Synthesis of Lipoteichoic Acid Carrier , Biochemical and Biophysical Research Communications, 59, 1131-6 Gold, M.H. Hahn, H.J. (1976) Role of a Mannosyl Lipid Intermediate in the Synthesis of Neurospora crassa Glycoproteins, Biochemistry, 15,1808-14 Goldemberg, S.H. Marechal, L.R. (1963) Biosynthesis of Paramylon in Euglena gracilis, Biochimica et Biophysica Acta, 71, 743-4... [Pg.323]

Biosynthesis of Saccharomyces cerevisiae LK 2G12 Mannan , FEBS Letters, 14,109-13 Sentendreu, R. Lampen, J.O. (1972) Biosynthesis of Mannan in Saccharomyces cerevisiae. Isolation of a lipid Intermediate and its Identification as a Mannosyl-1-phosphoryl Polyprenol , FEBS Letters, 27, 331-4 Sharma, C.B., Babczinski, P., Lehle, L. Tanner, W. (1974) The Role of Dolichol-monophosphate in Glycoprotein Biosynthesis in Saccharomyces cerevisiad, European Journal of Biochemistry, 46, 35-41... [Pg.335]

Japanese Journal of Experimental Mediciney 37, 79-81 Tanner, W. (1969) A Lipid Intermediate in Mannan Biosynthesis in Yeast , Biochemical and Biophysical Research Communications, 35,144-150 Tanner, W., Babczinski, P., Marriott, M., Hasilik, A. Lehle, L. (1979) Glycosylation of Intra- and Extra-cellular Yeast Glycoproteins , Biochemical Society Transactions, 7, 329-31... [Pg.338]

Glycosyl-transfer reactions in the nuclear membranes of Saccharomyces cerevisiae are mediated by a lipid intermediate. Studies with UDP-2-acetamido-2-deoxy-D-glucose and GDP-o-mannose revealed that relatively high levels of P -2-acetamido-2-deoxy-D-glucopyranosyl P -dolichyl pyrophosphate and a D-mannosylated protein are formed, consistent with the role of P -2-acetamido-2-deoxy-D-glucopyranosyl P -dolichyl pyrophosphate as an intermediate in the glycosylation of nuclear glycoproteins. [Pg.443]

Derivatives of cholesterol which inhibit the biosynthesis of cholesterol in aortic smooth muscle, presumably by suppressing the activity of 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase, also effect a corresponding decrease in the levels of glycosylated lipid intermediates with an apparent inhibition of the biosynthesis of glycoproteins. ... [Pg.332]

In the overwhelming majority of cases, the nucleotide sugars appear to be the immediate precursors of the glycoprotein-bound sugars, but evidence has been accumulating in recent years for the participation of lipid intermediates in certain of the biosynthetic reactions. In particular, incorporation of mannose into glycoproteins may take place via a lipid intermediate, and the details of this process will be discussed later (see Section IV, A, 5, b). [Pg.17]

Lipid intermediates are formed during the biosynthesis of glycoproteins in microsomes. Column chromatography was used to separate dolichyl D-[ C]mannosyI phosphate from a D-[ C]manno-oligosaccharide which was also bound to lipid after removal of the lipid, the oligosaccharide fraction appeared to be heterogeneous in its reaction with concanavalin A. [Pg.418]

Spiro, R. G., M. J. Spiro, and A. M. Adamany, Enzymic assembly of the carbohydrate units of glycoproteins and the role of lipid intermediates, Biochem. Soc. Symp., 1974, 37-55. [Pg.1236]

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Lipid intermediates

Lipid intermediates, glycoprotein biosynthesis

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