Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Linoleic acid radical

De Groot, J.M.C., Garssen, G.J., Vliegenthart, J.F.G. and Boldingh, J. (1973). The detection of linoleic acid radicals in the anaerobic reaction of liproxygenase. Biochim. Biophys. Acta 326, 279-284. [Pg.34]

Sekiya, J. Aoshima, H., Kajiwara, T., Togo, T. and Hatanaka, A. (1977). Purification and some properties of potato tuber lipoxygenase and detection of linoleic acid radical in the enzyme reaction. Agric. Biol. Chem. 41, 827-832. [Pg.36]

For the assessment of the antioxidant activity of canolol, the 3-carotene-linoleic acid assay as well as the DPPH method was used. Using the 3-carotene-linoleic acid assay model system, rapid discolouration was observed in the absence of an antioxidant. The free linoleic acid radical, formed by abstraction of a hydrogen atom from one of its methylene gronps, attacks the P-carotene molecnles resnlting in the loss of double bonds and its characteristic orange colour. The rate of bleaching of the P-carotene solution was determined by measuring the difference between the initial... [Pg.324]

Structure and Mechanism of Formation. Thermal dimerization of unsaturated fatty acids has been explaiaed both by a Diels-Alder mechanism and by a free-radical route involving hydrogen transfer. The Diels-Alder reaction appears to apply to starting materials high ia linoleic acid content satisfactorily, but oleic acid oligomerization seems better rationalized by a free-radical reaction (8—10). [Pg.114]

Lipid hydroperoxides are either formed in an autocatalytic process initiated by hydroxyl radicals or they are formed photochemically. Lipid hydroperoxides, known as the primary lipid oxidation products, are tasteless and odourless, but may be cleaved into the so-called secondary lipid oxidation products by heat or by metal ion catalysis. This transformation of hydroperoxides to secondary lipid oxidation products can thus be seen during chill storage of pork (Nielsen et al, 1997). The secondary lipid oxidation products, like hexanal from linoleic acid, are volatile and provide precooked meats, dried milk products and used frying oil with characteristic off-flavours (Shahidi and Pegg, 1994). They may further react with proteins forming fluorescent protein derivatives derived from initially formed Schiff bases (Tappel, 1956). [Pg.316]

JiAZ s,ZHOU B, YANG L, wu L M and LIN z L (1998) Autioxidant synergism of tea polyphenols and a-tocopherol against free radical induced peroxidation of linoleic acid in solution, J Chem Soc Perkin Trans, II, 911-15. [Pg.342]

Thompson, S. and Smith, M.T. (1985). Measurement of the diene conjugated from of linoleic acid in plasma by high performance liquid chromatography. A questionable non-invasive assay of free radical activity. Chem. Biol. Interactions 55, 357-366. [Pg.198]

Figure 10.7 Autoxidation of a linoleic acid ester. In step 1 the reaction is initiated by the attack of a radical on one of the hydrogen atoms of the -CH2-group between the two double bonds this hydrogen abstraction produces a radical that is a resonance hybrid. In step 2 this radical reacts with oxygen in the first of two chain-propagating steps to produce an oxygen-containing radical, which in step 3 can abstract a hydrogen from another molecule of the linoleic ester (Lin-H). The result of this second chain-propagating step is the formation of a hydroperoxide and a radical (Lin ) that can bring about a repetition of step 2. Figure 10.7 Autoxidation of a linoleic acid ester. In step 1 the reaction is initiated by the attack of a radical on one of the hydrogen atoms of the -CH2-group between the two double bonds this hydrogen abstraction produces a radical that is a resonance hybrid. In step 2 this radical reacts with oxygen in the first of two chain-propagating steps to produce an oxygen-containing radical, which in step 3 can abstract a hydrogen from another molecule of the linoleic ester (Lin-H). The result of this second chain-propagating step is the formation of a hydroperoxide and a radical (Lin ) that can bring about a repetition of step 2.
This assay, developed by Taga and others (1984), is based on the coupled oxidation of (3-carotene and linoleic acid. The method estimates the relative ability of antioxidant compounds to scavenge the radical of linoleic acid peroxide (LOO ) that oxidizes (3-carotene in the emulsion phase. [Pg.286]

Hydroxy-10,12-octadecadienoic acid, which is formed by the reduction of 9-HPODE, was identified in the erythrocyte membrane phospholipid of diabetic patients [83]. It was suggested that this compound was formed as a result of glucose-induced oxidative stress in the reaction of hydroxyl radicals with linoleic acid. [Pg.782]

Inhibition and stimulation of LOX activity occurs as a rule by a free radical mechanism. Riendeau et al. [8] showed that hydroperoxide activation of 5-LOX is product-specific and can be stimulated by 5-HPETE and hydrogen peroxide. NADPH, FAD, Fe2+ ions, and Fe3+(EDTA) complex markedly increased the formation of oxidized products while NADH and 5-HETE were inhibitory. Jones et al. [9] also demonstrated that another hydroperoxide 13(5)-hydroperoxy-9,ll( , Z)-octadecadienoic acid (13-HPOD) (formed by the oxidation of linoleic acid by soybean LOX) activated the inactive ferrous form of the enzyme. These authors suggested that 13-HPOD attached to LOX and affected its activation through the formation of a protein radical. Werz et al. [10] showed that reactive oxygen species produced by xanthine oxidase, granulocytes, or mitochondria activated 5-LOX in the Epstein Barr virus-transformed B-lymphocytes. [Pg.806]

Belkner et al. [32] demonstrated that 15-LOX oxidized preferably LDL cholesterol esters. Even in the presence of free linoleic acid, cholesteryl linoleate continued to be a major LOX substrate. It was also found that the depletion of LDL from a-tocopherol has not prevented the LDL oxidation. This is of a special interest in connection with the role of a-tocopherol in LDL oxidation. As the majority of cholesteryl esters is normally buried in the core of a lipoprotein particle and cannot be directly oxidized by LOX, it has been suggested that LDL oxidation might be initiated by a-tocopheryl radical formed during the oxidation of a-tocopherol [33,34]. Correspondingly, it was concluded that the oxidation of LDL by soybean and recombinant human 15-LOXs may occur by two pathways (a) LDL-free fatty acids are oxidized enzymatically with the formation of a-tocopheryl radical, and (b) the a-tocopheryl-mediated oxidation of cholesteryl esters occurs via a nonenzymatic way. Pro and con proofs related to the prooxidant role of a-tocopherol were considered in Chapter 25 in connection with the study of nonenzymatic lipid oxidation and in Chapter 29 dedicated to antioxidants. It should be stressed that comparison of the possible effects of a-tocopherol and nitric oxide on LDL oxidation does not support importance of a-tocopherol prooxidant activity. It should be mentioned that the above data describing the activity of cholesteryl esters in LDL oxidation are in contradiction with some earlier results. Thus in 1988, Sparrow et al. [35] suggested that the 15-LOX-catalyzed oxidation of LDL is accelerated in the presence of phospholipase A2, i.e., the hydrolysis of cholesterol esters is an important step in LDL oxidation. [Pg.810]

In the case of ubiquinones we have already considered the ability of quinones to react with superoxide and other free radicals. Naphthoquinones, vitamin K and its derivatives, especially menadione, are the well known producers of superoxide through redox cycling with dioxygen. However, in 1985, Canfield et al. [254] have shown that vitamin K quinone reduced the oxidation of linoleic acid while vitamin K hydroquinone stimulated lipid peroxidation. Surprisingly, later on, conflicting results were reported by Vervoort et al. [255] who found that only hydroquinones of vitamin K and its analogs inhibited microsomal lipid peroxidation. [Pg.879]


See other pages where Linoleic acid radical is mentioned: [Pg.25]    [Pg.68]    [Pg.1422]    [Pg.355]    [Pg.226]    [Pg.258]    [Pg.71]    [Pg.25]    [Pg.68]    [Pg.1422]    [Pg.355]    [Pg.226]    [Pg.258]    [Pg.71]    [Pg.498]    [Pg.332]    [Pg.25]    [Pg.25]    [Pg.154]    [Pg.175]    [Pg.68]    [Pg.306]    [Pg.390]    [Pg.774]    [Pg.775]    [Pg.805]    [Pg.810]    [Pg.818]    [Pg.850]    [Pg.853]    [Pg.896]    [Pg.924]    [Pg.917]    [Pg.87]    [Pg.51]    [Pg.52]    [Pg.69]    [Pg.117]    [Pg.140]    [Pg.131]    [Pg.342]    [Pg.29]    [Pg.335]    [Pg.320]   
See also in sourсe #XX -- [ Pg.71 ]




SEARCH



Acid radicals

Acidic radicals

Linoleic acid

Linoleic acid acids

Linoleic acid/linoleate

© 2024 chempedia.info