Haplotypes variation

Stephens JC, Schneider JA, Tanguay DA, Choi J, Acharya T, Stanley SE et al. Haplotype variation and linkage disequilibrium in 313 human genes. 

Ware JH. The limitations of risk factors as prognostic tools. N EnglJ Med 2006,355 2615-2611. Conrad DF, Jakobsson M, Coop G et al. A worldwide survey of haplotype variation and linkage disequilibrium in the human genome. Nat Genet 2006 38 1251-1260. 

Hedenas, L. (2009b). Haplotype variation of relevance to global and European phylogeography in Sarmentypnum exannulatum (Bryophyta Calliergonaceae). Journal of Bryology 31,145-158. 

Steenland, K., Bray, 1., Greenland, S., and Boffetta, P. Empirical Bayes adjustments for multiple results in hypothesis-generating or surveillance studies. Cancer Epidemiol. Biomarkers Prev. 2000 9 895 903. Stephens, J.C., Schneider, J.A., and Tanguay, DA. Haplotype variation and linkage disequilibrium in 313 human genes. Science 2001 293 1048. 

Clark AG, Weiss KM, Nickerson DA, Taylor SL, Buchanan A, Stengard J et al. Haplotype structure and population genetic inferences from nucleotide-sequence variation in human lipoprotein lipase. Am J Hum Genet 1998 63 595— 612. 

Bonnen PE, Story MD, Ashorn CL, Buchholz TA, Weil MM, Nelson DL. Haplotypes at ATM identify coding-sequence variation and indicate a region of extensive linkage disequilibrium. Am J Hum Genet 2000 67[6] 1437-1451. 

Fallin D, Cohen A, Essioux L, Chumakov I, Blumenfeld M, Cohen D et al. Genetic analysis of case/control data using estimated haplotype frequencies application to APOE locus variation and Alzheimer s disease. Genome Res 2001 11[1] 143—151. 

There may also be a compromise position in this regard in that, rather than systematic examination of the entire genome, it may be possible to systematically examine all genes. To this end, efforts are being made to enumerate the full array of genetic variation in all genes, establish their haplotypes (Stephens et al., 2001), and employ so-called "haplotype tags" to... 

This chapter reviews recent progress in irinotecan pharmacogenetics, including novel functional genetic variations and the haplotype structures of UGTlAs, with particular focus on the cumulative data showing the clinical relevance of UGTIAI... 

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