Linctus

Actifed Compound Linctus Sanabronchiol (Kalda) Fenesin DM (Dura as j... 

Rinurel linctus (Parke Davis)-comb. wfm Ethnine (Purdue Frederick) wfm Simplex (Purdue Frederick) wfm... 

Actifed Compound Linctus triprolidine, pseudoephedrine, dextromethoi... 

In order to selectively extract base A 5 ml of the linctus is mixed with 1 5 ml of phosphate buffer pH 6.7 and extracted once with 60 ml of chloroform. 

Assay of active ingredients in a linctus using a single point calibration for each analyte... 

The linctus is sugar free so that it is sufficiently non-viscous to be measured with a pipette rather than weighed. An aliquot of the linctus (5 ml) is made basic by addition of 1 ml of 10 M ammonia solution. The aqueous layer is extracted with... 

X 10 ml of chloroform. The chloroform layers are combined and evaporated to dryness using a rotary evaporator. The residue is dissolved in ca 10 ml of methanol and transferred to a 100 ml volumetric flask and then diluted to volume with mobile phase. The areas of the peaks obtained from the linctus extract are compared with a solution containing pseudoephedrine.HCl, dextromethorphan.HBr and triprolidine.HCl (structures shown in Fig. 11.14) at the same concentrations as would be expected in the linctus extract. 

The HPLC chromatogram of an extract from a linctus containing pseudoephedrine, dextromethorphan, triprolidine and methylparaben. ODS column 25 cm x 4.6 mm, mobile phase acetonitrile/0.05 M phosphate buffer pH 6.8 (35 65) 1 ml/min. UV monitoring at 260 nm. 

An analysis is carried out on codeine linctus stated to contain 0.3% w/v of codeine... 

The linctus is diluted to 50 ml with water prior to analysis... 

Area of codeine peak obtained by analysis of the linctus = 86 983... 

Linctus are viscous, liquid oral preparation containing high proportions of syrup (sugar) and glycerin (for viscosity and its sweet nature) which produce a demulcent affect on the mucous membrane of the throat. 

Certain lozenges, linctus and cough drops containing glycerine, liquorice and syrups. ... 

Methadone detoxification is nearly always in the form of the Img in 1ml mixture. Some individuals doing a detoxification from injectable maintenance wish to reduce in that form in the first instance, but clearly a switch to mixture should be made sooner or later, possibly using combinations of the two for a period. Methadone tablets are increasingly discouraged, while the 2 mg in 5 ml linctus may be useful at very low dosages, for ease of measurement. 

The most commonly used opiate substitute is methadone which has been available since the Second World War. It is a potent analgesic with a long half life, and thus once substituted for diamorphine can be reduced over a variable period of time. It is available in ampoules (for injection), tablets, linctus (2 mg in 5 ml), and mixture (1 mg in 1 ml). The use of ampoules and tablets is to be discouraged and many centres now are using the methadone mixture. This can be prescribed by any medical practitioner and requires no central licence. The use of ampoules and tablets has led to abuse, and these preparations have more of a black market value than the mixture. The amount of mixture used will depend on the amount of street heroin consumed and its potency, but it is usual to start at a safe dosage of between 30 and 50 mg daily for opiate dependents consuming half to one gramme... 

In a randomized, double-bhnd, placebo-controlled trial of the efficacy of intravenous methylnaltrexone (0.015-0.095 mg/kg) in treating chronic methadone-induced constipation in 22 patients attending a methadone maintenance program (oral methadone linctus 30-100 mg/day), methylnaltrexone induced immediate bowel movements in all subjects (32). There were no opioid withdrawal symptoms or significant adverse effects. 

Proprietary Names. Adaphol Dia-Tuss Duro-Tuss Pectolin Sancos Sedlingtus Triopaed Tussinol. It is an ingredient of Copholco, Copholcoids, Davenol, Expulin, Falcodyl, Pavacol-D, PEM, Pholcolix, Pholcomed (linctus), Pholtex, Rinurel (linctus), Rubelix, and Triocos. 

Benylin Decongestant, 944 Benylin (fortified linctus), 520 Benzalchlor-50,379 Benzaldehyde, 352, 379 Benzalkonium bromide, xvii... 

Label Codeine Linctus [or NP]. Take 5 ml twice a day and on retiring. 

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