Opiate linctus

Spans and Tweens have been used to overcome similar problems in the formulation of medicines for internal use. The solubilization of resinous components of tinctures such as benzoin and myrrh in aqueous vehicles and the incorporation of water-soluble ingredients into oily vehicles has been discussed by Stoklosa and Ohmart [230]. Gerding and Sperandio [229] give examples of mixtures of tinctures and fluid extracts which, on addition of polysorbate 20, will not precipitate on dilution. Cetomacrogol 1000 added in small amounts to opiate linctus of squill, syrup of ginger, compound mixtures of camphor, and of lobelia and stramonium has a similar clearing action [207]. 

Opiate Linctus of Squill, B.P.C, (Gee s Linctus). Consists of equal... 

Opiate Linctus of Squill for Infants, B.P.C, A similar preparation to the above, diluted with glycerin and syrup. 

The assay of this preparation follows that for Opiate Linctus of Squill but using three times the weight of sample and diluting to 50 ml before taking a 20-ml aliquot for colorimetric assay. 

Pastilles of Opiate Linctus of Squill, B.P.C. (Gee s Linctus Pastilles). Pastilles containing active ingredients equivalent to 30 minims of Gee s Linctus are prepared either with a glyco-gelatin or acacia and sucrose basis. For the nitrosomorphine assay a double extraction is necessary. 

The most commonly used opiate substitute is methadone which has been available since the Second World War. It is a potent analgesic with a long half life, and thus once substituted for diamorphine can be reduced over a variable period of time. It is available in ampoules (for injection), tablets, linctus (2 mg in 5 ml), and mixture (1 mg in 1 ml). The use of ampoules and tablets is to be discouraged and many centres now are using the methadone mixture. This can be prescribed by any medical practitioner and requires no central licence. The use of ampoules and tablets has led to abuse, and these preparations have more of a black market value than the mixture. The amount of mixture used will depend on the amount of street heroin consumed and its potency, but it is usual to start at a safe dosage of between 30 and 50 mg daily for opiate dependents consuming half to one gramme... 

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See also in sourсe #XX -- [ , ]

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