Linalool-8-carboxylic acid

Conyza canadensis (L.) Cronq. Xiao Fei Peng (aerial part) Essential oils, matricaria ester, dehydromatricaria ester, linoleyl acetate, limonene, linalool, centaur X, dephenyl methane-2-carboxylic acid, cumulene, O-benzylbezoic acid.48 Relieve swelling, itchiness, treat intestine and liver infection, a detoxicant, externally for skin eczyma, wounds, pain caused by arthrritis, toothache. 

Three new monoterpenoid lactones, (28)—(30), isolated from the urine of koala bears fed on Eucalyptus punctata, appear to have arisen from the cyclization of carboxylic acids formed as hydrolysis products of glucuronide conjugates from the metabolism of a- and /3-pinenes.70 Linalool injected into various plant species has been claimed to be converted into a-terpineol and other monoterpenoids.71 However, direct interconversions cannot be inferred from this type of non-radioactive tracer study. The terpenoids alleged to be produced may well be stress metabolites or be formed b secondary processes that perturb the usual pattern of terpenoid formation. 

Monoterpenoids are responsible for fragrances and flavors of many plants and thus their products are used in perfumery and as spices. To date over 1,500 monoterpenoids are known, and these constitute acyclic, monocyclic, and bicyclic monoterpenoids (32), which occur in nature as hydrocarbons, alcohols, aldehydes, and carboxylic acids and their esters. Several acyclic monoterpenoid hydrocarbons are known, and these include trienes such as 3-myrcene (Cl), a-myrcene (C2), (Z)-a-ocimene (C3), ( )-a-ocimene (C4), (Z)-3-ocimene (C5), and ( )-P-ocimene (C6). 3-Myrcene and 3-ocimene are constituents of basil (Oci-mum basilicum, Labiatae) and bay (Pimenta acris, Myrtaceae), pettitgrain (Citrus vulgaris, Rutaceae) leaves, strobiles of hops (Humulus lupulus, Cannabaceae), and several other essential oils. Unsaturated acyclic monoterpene alcohol constituents of plants and their derived aldehydes play a signihcant role in the perfume industry. Some common acyclic monoterpene alcohols and aldehydes include geraniol (C7), linalool (C8) (a... 

Acylation catalyst.2 4-Pyrrolidinopyridine (1), like N,N-dimethyl-4-pyridinamine (3, 118-119), is a very effective catalyst for acylation of sterically hindered alcohols. In a typical procedure, the alcohol is treated with a carboxylic acid anhydride and an equimolar amount of the dialkylaminopyridine at room temperature. In preparations on a larger scale, 1 eq. of triethylamine is added to bind the acid formed in the acylation. For example, methyl cholate is converted into the triacetate at room temperature within 2 hr. using 4-pyrrolidinopyridine as catalyst. Acetylation with Ac20/pyridine at room temperature affords only the 3,7-diaeetate (the 12a-hydroxyl group is axial).3 4-Dialkylaminopyridines are particularly useful catalysts for acylation of add-sensitive tertiary alcohols such as linalool (2), which can be acetylated in 80% yield by this new procedure. 

The formation of the characteristic aroma of cocoa depends on a number of factors, such as good harvest, fermentation, drying and roasting of cocoa beans. Precursors of aromatic compounds are produced mainly by anaerobic fermentation of cocoa beans. The aroma of roasted beans is created largely by the Maillard reaction and caramehsation, and is represented by more than 400 compounds. The major components are aldehydes, sulfides, heterocyclic compounds, carboxylic acids and terpenoids. Important aldehydes are 2-methylpropanal and 2-methylbutanal, which recalls the smell of cocoa and malt, and ( )-2-phenyl-5-methylhex-2-enal (8-201), which resembles chocolate. The latter aldehyde is formed by aldol condensation of another important aroma component, 3-methylbutanal with phenylacetaldehyde, and dehydration of the aldolisation product. Linalool and 2-phenylethanol... 

Bernier et al. extensively reviewed attraction-inhibitors. Included in the review were compounds produced by plants such as catnip oil (specifically the isomers of nepetalactone), geraniol, linalool, citronellol and citronellal, and human-produced compounds. In human-produced compounds, attraction-inhibition was observed for some carboxylic acids (saturated acid combinations of Cg-C,o... 

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