Limbic brain regions

The initial evidence for abnormalities of the hippocampus in schizophrenia came from postmortem and structural imaging studies. A study exploring volume changes in limbic brain regions reported... 

Through the pathways of the mesolimbic system (a term introduced by Ungerstedt in 1971), the basal ganglia provide an interface with limbic brain regions. This interface has been repeatedly implicated in psychiatric diseases, such as schizophrenia and other affective disorders, as well as in reward and addiction. 

Ciccocioppo R, Sanna PP, Weiss F (2001) Cocaine-predictive stimulus induces drug-seeking behavior and neural activation in limbic brain regions after multiple months of abstinence reversal by DI antagonists. Proc Natl Acad Sci USA 98(4) 1976-1981. 

Volk, H.A., Potschka, H., and Loscher, W. (2004) Increased expression of the multidrug transporter P-glycoprotein in limbic brain regions after amygdala-kindled seizures in rats. Epilepsy Research, 58 (1), 67-79. 

The discovery that D and receptors are preferentially expressed in limbic areas has led to efforts to identify selective inhibitors for these receptors that might have antipsychotic efficacy and low risk of extrapyramidal effects. Clozapine has modest selectivity for D receptors over other DA receptor types. D receptors, preferentially localized in cortical and limbic brain regions in relatively low abundance, are upregulated after repeated administration of most typical and atypical antipsychotic drugs. These receptors may contribute to clinical antipsychotic actions, but agents that are selective or mixed DyS antagonists have not proved effective in the treat-... 

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