Preferential localization

The development of so-called photodynamic therapy uses lasers for treatment of cancer. The patient is injected with a substance called hematoporphyrin derivative [68335-15-9] which is preferentially localized in cancerous tissues. The patient is later irradiated with laser light, often with a dye laser at a wavelength around 630 nm. The light energy catalyticaHy photooxidizes the hematoporphyrin derivative, releasing materials which kill the nearby cancerous tissue. Normal tissue which did not retain the chemical is not harmed. Photodynamic therapy offers promise as a new form of cancer treatment. 

From the foregoing it is clear that indentation anisotropy is a consequence of high molecular orientation within highly oriented fibrils and microfibrils coupled with a preferential local elastic recovery of these rigid structures. We wish to show next that the influence of crystal thickness on AMH is negligible. The latter quantity is independent on 1 and is only correlated to the number of tie molecules and inter-crystalline bridges of the oriented molecular network. 

Transversely, mammalian biomembranes exhibit a general pattern for preferential localization of choline-containing phospholipids [such as phosphatidylcholine (PC) and... 

Preferential local cyclic synthesis/degradation of kinetically stable... 

An early account194 describes an attempt to use 64Cu complexes of haematoporphyrin, protoporphyrin, uroporphyrin, and coproporphyrin to detect tumors preferential localization in tumors was not observed. It needs to be recognized that metalation can change solution... 

Intense contact (compression or rubbing) Same as for light contact plus the following Preferential local heating (to cause ion migration or electron transfer) Rupture of chemical bonds (Asymmetry of either surface structure or nature of contact or both is necessary to achieve charging)... 

As observed in many theoretical studies of symmetric radicals (92), a HF wavefunction describing it ->- tt excited states preferentially localizes the hole on one moiety leading to a broken symmetry structure of the states with unequal bond lengths for the minimum energy structure. Similarly, for the n tt ... 

Jenkins GM, Crow MT, Bilato C, et al, Increased expression of membrane-type matrix metalloproteinase and preferential local-itation of matrix metalloproteinase-2 to the neointima of balloon-injured rat carotid arteries. Circulation I 998 97 82-90. 

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