Lignans breast cancer

McCann, S.E., Moysich, K.B., Freudenheim, J.L., Ambrosone, C.B., and Shields, P.G., The risk of breast cancer associated with dietary lignans differs by CYP17 genotype in women, J. Nutr., 132, 3036, 2002. 

N.A. Phenol, lignan, oleic acid, linoleic acid, protein, vitamins , E, folic acid.165166 An antioxidant, antitumor, antimitotic, antiviral, prevent breast cancer. Internally for premature hair loss and graying, strengthen bones and teeth. 

Adlercreutz H, Fotsis T, Heikkinen R, Dwyer JT, Woods M, Goldin BR, Gorbach SL. 1982. Excretion of the lignans enterolactone and enterodiol and of equol in omnivorous and vegetarian postmenopausal women and in women with breast cancer. Lancet 2 1295-1299. 

Cotterchio M, Boucher BA, Kreiger N, Mills CA, Thompson LU. 2008. Dietary phytoestrogen intake-lignans and isoflavones-and breast cancer risk (Canada). Cancer Causes Control 19 259-272. 

In contrast to lignans, few studies have been reported regarding the relationship between ALA and breast cancer. In a meta-analysis, Saadatian-Elahi et al. (2004) reported a significant protective effect of total n-3 fatty acids and breast cancer risk. In this assessment, three cohort and seven case-control studies were reviewed. The case-control studies revealed an inverse association between ALA and breast cancer risk. High dietary intakes of ALA were correlated with a reduced breast cancer risk (Franceschi et al., 1996). This study involved 2569 women with breast cancer and the result was supported by a cohort study conducted in the Netherlands (Voorrips et al., 2002). A significant inverse association was found between ALA content in breast adipose tissue and breast cancer risk (Klein et al., 2000 Maillard et al., 2002). Furthermore, ALA to LA ratio close to one was also significantly associated with lower breast cancer risk (Maillard et al., 2002). 

Chen, J. and Thompson, L.U. 2003. Lignans and tamoxifen, alone or in combination, reduce human breast cancer cell adhesion, invasion and migration in vitro. Breast Cancer Res. Treat. 80, 163-170. 

Magee, P.J., McGlynn, H., and Rowland, I.R. 2004. Differential effects of isoflavones and lignans on invasiveness of MDA-MB-231 breast cancer ceff in vitro. Cancer Lett. 208, 35-41. 

Power, K.A., Saarinen, N.M., Chen, J., and Thompson, L.U. 2004. Lignans (enterolactone and enterodiol) negate the proliferative effect of sioflavone (genistein) on MCF-7 breast cancer cells in vitro and in vivo (abstract). Proc. AACR 45, 878. 

Saarinen, N.M., Makela, S., and Satti, R. 2003. Mechanism of anticancer effects of lignans with a special emphasis on breast cancer. In Flaxseed in Human Nutrition (S.C. Cunnane and L.U. Thompson, eds), 2nd Ed., pp. 223-228. AOCS Press, Champaign, IL. 

Another lignan, taxiresinol, isolated from Taxus wallichiana, exhibited notable in vitro anticancer activity against colon, liver, ovarian and breast cancer [86]. 

Adlercreutz H.Does Fiber-rich food containing animal lignan precursors protect against both colon and breast cancer An extension of the Fiber Hypothesis . Gastroenterology >6 6 -66. 1984. 

Different lignans, including some known phytoestrogens, were evaluated for their effects on DNA synthesis in estrogen-dependent and independent human breast cancer cells. At 0.1-10 pM, enterolactone induced DNA synthesis by 150-235%, and at 20-90 pM it inhibited DNA synthesis by 50%. Inhibition of estrogen-dependent and independent breast cancer cells... 

Bergman Jungestrom, M., L.U. Thompson, and C. Dabrosin. 2007. Haxseed and its lignans inhibit estradiol-induced growth, angiogenesis, and secretion of vascular endothelial growth factor in human breast cancer xenografts in vivo. Clin. Cancer Res. 13(3) 1061-1067. 

Power, K.A., and L.U. Thompson. 2007. Can the combination of flaxseed and its lignans with soy and its isoflavones reduce the growth stimulatory effect of soy and its isoflavones on established breast cancer Mol. Nutr. Food Res. 51(7) 845-856. Prasad, K. 2005. Effect of chronic administration of Hgnan complex isolated from flaxseed on the hemopoietic system. Mol. Cell. Biochem. 270(1-2) 139-145. 

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