Taxus wallichiana

Navia-Osorio, A., Garden, H., Cusido, R.M. et al. (2002) Production of paclitaxel and baccatin III in a 20-L airlift bioreactor by a cell suspension of Taxus wallichiana. Planta Medica, 68, 336-340. 

P-Hydroxy-10-deacetylbaccatin III (75, 14P-OH-DAB) was first isolated from the needles of the Himalayan yew tree (Taxus wallichiana Zucc.) and its structure was determined by X-ray crystallographic analysis in 1992.93 Because of an extra hydroxyl group at the C-14 position, 14P-OH-DAB (75) has much higher water solubility than DAB (3), the key precursor of paclitaxel and docetaxel. We envisaged that new taxoids derived from 75 would improve water solubility and bioavailability, and also reduce hydrophobicity-related drug resistance. These improved... 

Another lignan, taxiresinol, isolated from Taxus wallichiana, exhibited notable in vitro anticancer activity against colon, liver, ovarian and breast cancer [86]. 

Miller, R.W.R., Powell, R.G., and Smith, C.R. Jr. (1981) Antileukemic alkaloids from Taxus wallichiana Zucc. Journal of Organic Chemistry, 46, 1469—1474. 

Mukherjee, S., Ghosh, B., Jha, T. B., Jha, S. 2002. Variation in content of taxol and related taxanes in eastern Himalayan populations of Taxus wallichiana. Planta Med. 68 757-759. 

Taxus wallichiana Zucc. (leaves and branches) Biflavones Sequoiaflavone (2) ginkgetin (7) sciadopitysin (15). Ginkgetin is an active leishmanicidal compound. Ginkgetin also showed a good antitrypanosomal activity. Qiu et ah, 1989[492] Weniger etal.,2006[86]. 

Nhut, D.T. Hien, N.T.T. Don, N.T. Khiem, D.V. (2007). In vitro shoot development of Taxus wallichiana Zucc., a valuable medicinal plant. In Jain, S.M. Haggman, H. (Ed(s).). Protocols for Micropropagation of Woody Trees and Fruits, Vol. 10, pp. 107-116. Springer-Verlag. 

The alkaloid cephalomannine (43) has been isolated from Taxus wallichiana (the compound name reflects the fact that plant source was originally considered to be a Cephalotaxus species) (Miller et al., 1981 Powell et al., 1979). This alkaloid has antitumor activity in KB cell lines. 

Taxol and seven other major taxoids (10-deacetylbaccatin III, baccatin IV, 1-hydroxybaccatin I, 2-acetoxybrevifoliol, brevifoliol, 2 -deacetoxydeciimamoyltaxi-nine J, 2 -deacetoxytaxinine J) were extracted from Taxus wallichiana and characterized on a C18 column (A = 228 nm). An 80/20 - 60/40 (at 20 min) 47/53... 

Baccatin III was the first compound of this class, isolated from the heartwood of Taxus baccata in 1966 by Chan et al., and its stmcture was elucidated [20]. Many compounds have been extracted from the bark of Taxus baccata, Taxus wallichiana, or Taxus brevifolia that differ only in the nature of the substituent at C-1, C-2, and C-4 positions. 

Miller RW, Powell RG, Smith CR Jr., Arnold E et al. 1981 Antileukemic alkaloids from Taxus wallichiana Zucc. J Org Chem 46 1469-1474... 

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