Lignan biosynthesis experiments

Jurasek L (1996) Experimenting with virtual lignin. In Lewis NG and Sarkanen S (eds), Lignin and lignan biosynthesis. American Chemical Society, Washington, DC, 276-93 Jurasek L (1998) Molecular modelling of fibre walls. Journal of Pulp and Paper Science, 24 1) 209-12... 

Lignans of another type, dicarboxylic acid lignans (p-hydroxycinnamate dimers), were isolated from liverworts (Hepaticopsida) and some vascular plants [11, 64]. Little is known about the biosynthesis of this class of lignans, but a feeding experiment demonstrated the conversion of caffeic acid to optically pure epiphyllic acid in a liyerwoTt Lophocolea heterophylla (Fig. 12.9) [65]. 

In 1933, Erdtman suggested [20] that the basic lignan structure involved the coupling of two phenylpropanoid monomer units. Isotope tracer experiments on lignans were later described [2,21,22]. Significant advances have however been made in the chemistry and biosynthesis of lignans by Lewis... 

Rahman, M. A., Katayama, T., Suzuki, T., Yoshihara, Y. and Nakagawa, T. (2007) Stereochemistry and biosynthesis of (-1-)—lyoniresinol, a syringyl tetrahydronaphthalene lignan in Lyonia ovalifolia var. elliptica It feeding experiments with C labeled precursors. /. INood Set, 53,114—20. 

The lignan (+)-sesamin and related lignans present in sesame seeds or its oil are specific inhibitors of A5-desaturase in polyunsaturated fatty acid biosynthesis in both microorganisms and animals [273,274], The results obtained in experiments with both a cell-free extract of the fungus Mortierella alpina and rat liver microsomes demonstrated that (+)-sesamin... 

Biosynthesis of some antimalarial lignans such as S -epi-aristoligone (33) from the roots of Holostylis reniformis [10a] had been investigated through detailed administration experiments with the radiolabeled precmsors by Lopes and coworkers [10b]. Similar to the well-known biosynthetic... 

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