Chain region

A for the Tb RITC-DPPE pair [412] is also consistent with Tb binding in the acyl chain region of the bilayer. 

On the basis of the h and C NMR, we have pictured the delivery site of BPA as illustrated in Fig. 15. There is trapped BPA between the lipid headgroup and hydrocarbon chain region most adjacent to the interface, with two methyl groups oriented toward inside... 

Compounds with conformationally restrained side chains, unsaturated side chains and aromatic side chains have been synthesised in order to better define the steric requirements of the binding site in the side-chain region. These are shown in Table 6.9. On average, the conformationally restrained... 

There is an abrupt decrease in the lateral diffusion coefficient of DPPC upon the phase transition from the GI phase to the Gi phase. This is because the acyl-chain region is being packed even more efficiently in the Gi phase than in the GI phase, and the hydrocarbon volume in the Gi phase is smaller than in the GI phase. Also, in the Gi phase, the lipid acyl-chains from the opposing bilayer leaflets interdigitate. In order for a phospholipid molecule to diffuse it has to circumvent the nearby interdigitated molecules which hinder diffusion. 

Typically, a series of steps is involved in the work carried out by chaperone molecules. Hsp70 operates on the protein as it is being formed on the ribosome. It recognizes extended or exposed protein chain regions that are more hydrophobic and acts to discourage unwanted association of these parts. It also acts to maintain the growing protein in a somewhat unfolded state. 

Fig. 2. Copper site in azurin. In this and subsequent figures the following conventions have been used, (a) The copper site is generally an enlargement of (b). The copper site is a dotted sphere, the ligand residues are represented by bonds connecting atoms in the side chain, and, where possible, the atoms bonded to the copper atom are identified by atom type. Ribbons represent portions of the backbone structure near the copper. In (b) of each figure, the main-chain polypeptide is represented by a ribbon fit to the main-chain coordinates, and the amino and carboxy termini are indicated by N and C, respectively, (c) A schematic version drawn from (b). Solid arrows represent main-chain regions participating in the /3 sheet roughly above the plane of the paper, while dotted or light arrows are the...

Figure 6. Schematic diagram of the O chain of Hb, chain regions that have been extrapolated from the five antigenic sites of sperm whale Mb, and the antigenic sites of the a chain that were localized to Hb with goat, rabbit, and mouse antisera. The numbers refer to the locations of the residues in the a chain. The asterisk indicates that, owing to differences in the sizes of the polypeptide chains of Mb and the subunit, the antigenic site 5 of Mb (residues 145-151) does not really have a full structural counterpart in the O chain. Reproduced with permission from Ref. 6.

Rowland and Labun developed a model which is suitable for crosslinked polymers using a Gaussian distribution of xc. This model is based on spin diffusion to locations of rapid spin-lattice relaxation and assumes that protons in the crosslink region have different relaxation times (Tlx) from those in the free chain region (Tlc)54) ... 

Cholesterol probably orients such that its hydroxyl group is in the polar (aqueous) portion of the lipid bilayer, while its hydrocarbon portion is in the nonpolar (fatty acid side-chain) region. 

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