Ligand coreceptors

These recqrtors are integral components of the wingless (Wilt) signaling cascade by acting as coreceptors to frizzled. Simultaneous binding of Wnt ligands to... 

The HIV-1 coreceptors CXCR4 and CCR5 bind to ligand members of a family of molecules known as chemokines, or chemotactic cytokines. While the hallmark function of these small proteins is the direction of leukocyte trafficking, they can also participate in cellular events such as activation and costimulation (Bajetto et al. 2(X)la). Members of the chemokine family can be classified as either homeostatic or inflammatory based on their temporal expression (Charo and Ransohoff 2006 Kim 2005). Although traditionally the CNS had been thought to be protected from immune acti-... 

Matloubian M, David A, Engel S, Ryan JE, Cyster JG. A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo. Nat Immunol 2000 1 298-304. 

Dealwis C, Fernandez EJ, Thompson DA, Simon RJ, Siani MA, Lolis E. Crystal structure of chemically synthesized [N33A] stromal cell-derived factor lalpha, a potent ligand for the HIV-1 fusin coreceptor. Proc Natl Acad Sci U S A 1998 95 6941-6. 

Babcock GJ, Farzan M, Sodroski J. Ligand-independent dimerization of CXCR4, a principal HIV-1 coreceptor. J Biol Chem 2003 278 3378-3385. 

The D, A or PS units may be metal coordination centres. Metal to ligand charge transfer (MLCT) in metal complexes (such as Ru(n) or Re(l)-diimine centres) has been extensively used for generating PeT processes [8.64-8.68, A. 10, A.20]. Our own work has been concerned with photoinduced charge separation in macropoly-cyclic coreceptors containing both a photosensitive porphyrin group and binding sites for silver(i) ions as acceptor centres. Thus, complexation of silver ions by the... 

Self-assembly may occur in repetitive chain ligands, acyclic coreceptors containing several identical binding subunits arranged linearly, if substrate binding to a given site is connected with binding to the other sites so that full site occupation is only compatible with a defined final architecture. 

Figure 5. Nucleobase quartet generated from diplatinated G, A, U base triplet and C. The coreceptor ligand 1-MeU is also involved in hydrogen bonding with the 1-MeC guest. [Reprinted with permission from (117).]...

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