Prospecting libraries

The DOCK combinatorial docking implementation [275] was also applied for the design of novel enzyme inhibitors [276, 277]. In one of these prospective examples, Haque et al. reported potent low-nanomolar plasmepsin II aspartyl-protease inhibitors [278] from a set of several focused libraries with a best Ki value of 2 nM (cf Figure 4.5f). 

Having validated the inverse screening approach for fom unrelated ligands, a prospective screening was carried out to identify the putative targets for representative compounds of a scaffold-focused combinatorial library (Fig. 11). 

The ability to use the developed QSAR model to screen compound libraries is an attractive prospect, yet is difficult to implement. Two types of compound... 

Allen, J.B., Walberg, M.W., Edwards, M.C., and Elledge, S.J. (1995) Finding prospective partners in the library the two-hybrid system and phage display find a match. Trends Biochem Sci 20 511-516. 

Cochrane Review). The Cochrane Library. Chichester John Wiley Sons Solberg U, Burkhart G Nilson M (2002). An overview of opiate substitution treatment in the European Union and Norway. International Journal of Drug Policy, 13, 477-84 Soyka M (2000). Substance misuse, psychiatric disorder and violent and disturbed behaviour. British Journal of Psychiatry, 176, 345-50 Spataro J, Mullen PE, Burgess PM, Wells DL Moss SA (2004). Impact of child sexual abuse on mental health. Prospective study in males and females. British Journal of Psychiatry, 184, 416-21... 

Sarko, C.R., Microwave-Accelerated Combinatorial Library Design and Development, ACS Prospectives Proceedings in Combinatorial Chemistry 2002, Leesburg, VA. 

A systematic review of randomized controlled trials has been performed to determine whether dexamethasone therapy in the first 15 days of life prevents chronic lung disease in premature infants (14). Studies were identified by a literature search using Medline (1970-97) supplemented by a search of the Cochrane Library (1998, Issue 4). Inclusion criteria were (a) prospective randomized design with initiation of dexamethasone therapy within the first 15 days of life (b) report of the outcome of interest and (c) less than 20% crossover between the treatment and control groups during the study period. The primary outcomes were mortality at hospital discharge and the development of chronic lung disease at 28 days of life and 36 weeks postconceptional age. The secondary outcomes were the presence of a patent ductus... 

The combination of the catalytic method and the three-phase separation could be applied to the parallel rapid synthesis of a small library of nine compounds of type 7 using the Giese reaction (eq. 5.3). The attractive prospect from this simple experiment arises from the very efficient workup protocol, allowing facile and quantitative separation even if excess reagents... 

On December 4, 1978, a new study of MThe United States Coal Industry Problems and Prospects was sent to the Members of the Permanent Subcommittee on Investigations by Senator Henry Jackson, the Chairman. This study was prepared by the Congressional Research Service of the Library of Congress. The study was prepared at the request of Senator Charles H. Percy, the ranking Minority member of the Subcommittee. 

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