Lethargic

This is not to imply that a full-throttle acceleration from rest to that speed is a maneuver frequently executed by the typical driver. The time to 60 mph is rather an easily measured parameter that seiwes as a surrogate for other performance metrics. A car that is slow from 0 to 60 mph will likely have slow response from 40 to 60 mph for freeway merging, or prove lethargic when climbing hills. Reflecting the market preference of the typical new-car buyer, for the average new U.S. passenger car, the acceleration time from 0 to 60 mph has decreased from about 14 seconds in 1975 to fewer than 11 seconds iti 1995. 

Sensorium. Patients with PCP intoxication can have a clear sensorium, or they can be disoriented, confused, stuporous, lethargic, or comatose. Signs of cerebral stimulation, such as pressured speech, verbigerations, and echolalia, may also occur. Frank psychotic symptoms, including hallucinations, delusions, and paranoid ideation, are not unusual. 

The patient may be alert and oriented, withdrawn or lethargic, or have an acute brain syndrome. There is a high incidence of rhabdomyolysis and hyperthermia in PCP-induced catatonic syndrome. Some patients have the neuroleptic malignant syndrome or develop it after administration of haloperidol. 

Lethargic—drowsy but easily aroused, unaware of some elements in the environment, or not spontaneously interacting appropriately with the examiner becomes fully aware and appropriately interactive when prodded minimally... 

Mental status Normal Normal to listless Normal to lethargic to comatose... 

The acute oral LDs° has been estimated to be 93 mg acrylonitrile/kg body weight (mg/kg) in rats (Back et al. 1972) and 27 mg/kg for mice (Ahmed and Patel 1981). Longer term intake (6 months) in dogs at 16 mg/kg/day resulted in early deaths. Animals lost weight and were described as depressed, lethargic, weak and emaciated prior to death. 

After 2 to 6 weeks, chickens were weak, anorectic, and lethargic 35% were anemic... 

Newt, Triturus cristatus, adults, held in tank with a zinc-plated base South African clawed frog, Xenopus laevis 200 to 3000 overa 7-day period Zinc-poisoned newts were lethargic, ate poorly, and had skin darkening prior to death. Zinc residues were elevated in kidney, brain, liver, and intestine, when compared to controls. The hippocampus region of the brain of poisoned newts contained zinc-rich cells 82... 

L. macrochirus 500 At 28 days, fish were lethargic, ate poorly, and swam erratically 3... 

Thirst Slightly increased Moderately increased Veiy thirsty or too lethargic to indicate... 

Impaired consciousness (e.g., ranging from obtunded to markedly lethargic and somnolent)... 

At 280,000 ppm, there was a loss of righting reflex within 10 min (10-min EC50) (Collins 1984). Rats exposed at 205,000 ppm were lethargic and developed tachypnea (Silber and Kennedy 1979a). At 359,300 ppm, trembling and tearing also occurred. No effect was observed after a similar exposure at 81,000 ppm. At 300,000 ppm, anesthesia of rats occurred in less than 2 min (Ritchie et al. 2001). During 15-min exposures at... 

Behaviorai effects Opioids produce sedation, but not as profoundly as CNS depressants like barbiturates or general anesthetics. A person administered an opioid is generally lethargic but arousable. 

At the 1000 ppm rate, fish become lethargic within one day, started to die by day 3 and were all dead by day 15. Additional fish, added on day 16, continued to die, but at a much slower rate in the W sediment tanks (Table II). A few fish also died in the 100 ppm tanks, necessitating the addition of more fish on day 50. TLC analysis of the fish extracts show that DDT decreased slowly with time, possibly accounting for the toxic response (Figure 3). On day 3 about 90% of the total extracted from fish was DDT which decreased slowly to 60 to 70% by day 57. DDD and polar metabolite increased slowly with time. The concentration of DDT in fish from the W sediment tanks remained 10 to 20% higher than fish from the W/0 sediment tanks. 

Rats exposed to 42,000 ppm became hyperactive within the first 7 minutes, and at the end of 7 minutes they appeared lethargic and ataxic. After 95 minutes, the animals were completely anesthetized. There was no mortality when the exposure was terminated at the end of 5 hours, and most of the animals recovered completely within 40 minutes. Edema and alveolar hemorrhage were present in animals killed at termination of the single exposure, whereas bronchiolitis and pneumonitis were observed in rats killed 9 days after exposure. 

Concentrations of oxygen in the inspired air of 12-16% cause tachypnea, tachycardia, and slight incoordination. Air containing 6-10% oxygen causes nausea, lethargic movements, and unconsciousness breathing less than 6% oxygen produces convulsions, followed by apnea and cardiac arrest. ... 

Lactation Benzodiazepines are excreted in breast milk (lorazepam not known). Chronic diazepam use in nursing mothers reportedly caused infants to become lethargic and to lose weight do not give to nursing mothers. 

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