Leptophos

Certain OP compounds including DFP, mipafox, and leptophos Organomercury and organolead compounds... 

A few OP compounds cause delayed neuropathy in vertebrates because they inhibit another esterase located in the nervous system, which has been termed neuropathy target esterase (NTE). This enzyme is described in Chapter 10, Section 10.2.4. OPs that cause delayed neuropathy include diisopropyl phosphofluoridate (DFP), mipafox, leptophos, methamidophos, and triorthocresol phosphate. The delay in the appearance of neurotoxic symptoms following exposure is associated with the aging process. In most cases, nerve degeneration is not seen with initial inhibition of the esterase but appears some 2-3 weeks after commencement of exposure, as the inhibited enzyme undergoes aging (see Section 16.4.1). The condition is described as OP-induced delayed neuropathy (OPIDN). 

Neuropathy target esterase (NTE) An esterase of the nervous system whose inhibition by certain OPs (e.g., mipafox, leptophos) can lead to the development of delayed neuropathy. 

Lepidolite, rubidium-bearing, 27 818 Lepirudin, 4 100, lOOt, 101 Leptin, 3 96-97 Lepton accelerator, 23 862 Leptons, 27 297, 298, 299 conservation of, 27 305 Leptophos, 4 358t Lercanidipine, 5 132-133... 

United States (Texas) Leptophos (Phosvel) At least 9 employees suffer serious neurological problems following exposure to insecticide during manufacturing process... 

The Increase in LD q was highest for the chlorinated insecticide, endrln (200%), followed by the organophosphate Insecticide, Cyolane (154%), the phosphorothioate insecticide leptophos (123%), and the carbamate insecticide, Zectran (87%). 

Leptophos [21609-90-5], O-methyl 0-(4-bromo-2,5-dichlorophenyl) phenylphosphonothioate (80) (mp 71°C), is soluble in water to 0.03 mg/L. The rat oral LD5Qs are 53, 45 mg/kg. Leptophos has been extensively used as a cotton insecticide but is a delayed neurotoxin. 

Leptophos 0-(4 bromo-2,5-dichlorophenyl) O-Methyl phenyl-phosphorothionate... 

Import, export, manufacture, and possession of hazardous substances have been controlled under the Hazardous Substances Act, 1992. However, banning of the import or severely restricted uses of chemicals had been notified in the Ministerial Notifications since 1977. Two insecticides, namely chlordimeform and leptophos were the first two of the banned chemicals in 1977. According to the Act, Ministerial Notifications of the Ministry of Industry were issued to harming of nine specified POPs pesticides usage since 1980 (Table 10.4). Only seven specified POPs pesticides were imported and widely used in Thailand, namely aldrin, chlordane, DDT, dieldrin, endrin, heptachlor, and toxaphene, whereas hexachlorobenzene and mirex have never been imported. Although... 

---