Lectin novel

Hepatocellular carcinoma (HCC) develops in patients with chronic liver diseases associated with hepatitis B and hepatitis C vims infections with high incidences. Here, an acyclic retinoid has been shown to suppress the posttherapeutic recurrence after interferon-y or glycerrhicin treatment in cirrhotic patients who underwent curative treatment of preceding tumors. The retinoid induced the disappearance of serum lectin-reactive a-fetoprotein (AFP-L3), a tumor marker indicating the presence of unrecognizable tumors in the remnant liver, suggesting a deletion of such minute (pre)malignant clones (clonal deletion). As a molecular mechanism of the clonal deletion, a novel mechanism of... 

SPARVOLIF, GALLO A, MARiNELLi D, SANTUCCi A, BOLLiNi R (1998) Novel lectin-related proteins are major components in lima bean Phaseolus lunatus L.) seeds. Biochim Biophys Acta. 1382 311-23. 

Sugai T., Sugitani M. and Onoda N. (2000). Novel subdivisions of the rat accessory olfactory bulb revealed by the combined method with lectin histochemistry, electrophysiological and optical recordings. Neuroscience 95, 23-32. 

Loukas, A.C., Mullin, N.P., Tetteh, K.K.A., Moens, L. and Maizels, R.M. (1999) A novel C-type lectin secreted by a tissue-dwelling parasitic nematode. Current Biology 9, 825-828. 

C. F. Brewer, M. C. Miceli, and L. G. Baum, Clusters, bundles, arrays and lattices Novel mechanisms for lectin-saccharide-mediated cellular interactions, Carr. Opin. Struct. Biol., 12 (2002) 616-623. 

Christensen et al. [93] successfully obtained a divalent cluster having -600-1500 enhanced binding properties. We have also demonstrated that dendritic mannosides such as 66 (Scheme 11) can provide up to 100-fold higher affinity (on a per-mannoside basis) when used to inhibit the binding of plant lectins (Concanavalin A and pea lectins) to yeast mannan [85]. As these interactions are at the origin of host infections by fimbriated bacteria, mannoside dendrimers can form the basis of novel antiadhesin molecules. 

Peumans, W. J., H. C. Winter, V. Bemer, and L. Van-Leuven. 1997. Isolation of a novel plant lectin with an unusual specificity from Calystegia sepium. Glycoconjugate J. 14 259-265. 

In recent years, as interest in the properties of biological membranes has increased, researchers have used lectins to study the role of the binding of multivalent ligands to the plasms membrane in the induction of specific biological responses. This report will detail the use of lectins to study the structure of the carbohydrate moiety of lymphocyte surface bound H-2 glycoproteins. Furthermore, it will describe a novel lectin-induced perturbation of the metabolism of in vitro cultured fibroblasts which results in the massive accumulation of lysosomes in these cells. This response is greatly reduced in cells which have been transformed by oncogenic viruses. 

Boyington, J. C., Riaz, A. N., Patamawenu, A., Coligan, J. E., Brooks, A. G., and Sun, P. D. (1999). Structure of CD94 reveals a novel C-type lectin fold Implications for the NK cell-associated CD94/NKG2 receptors. Immunity 10(1), 75-82. 

J. Bouckaert, T. Hamelryck, L. Wyns, and R. Loris. 1999. Novel structures of plant lectins and their complexes with carbohydrates Curr. Opin. Struct. Biol. 9 572-577. (PubMed)... 

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