LC-MS testing for CDG

Improved HPLC methods for the separation and quantihcation of transferrin glycoforms, based on anion-exchange chromatographic separation followed by selective photometric detection at 460 70 nm or MS detection, are useful for the detection and monitoring of 

Carbohydrate-deficient transferrin as a marker of chronic alcohol abuse a critical review of preanalysis, analysis, and interpretation, Clin. Chem., Al, 13-27 (2001). 

de Jong, R. Feelders, W.L. van Noort and H.G. van Eijk, Transferrin microheterogeneity as a probe in normal and disease states, Glycoconj. J., 12, 219-226 (1995). 

Stibler, Carbohydrate-deficient transferrin in serum a new marker of potentially harmful alcohol consumption reviewed, Clin. Chem., 31, 2029-2037 (1991). 

Marquardt and J. Denecke, Congenital disorders of glycosylation review of their molecular bases, clinical presentations and specific therapies, Eur. J. Pediatr., 162, 359-379 (2003). 

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