Laxatives comparative studies

Comparative studies In a randomized study, patients took Pico-Salax (a small-volume, osmotically active laxative containing sodium picosulfate lOmg -I- magnesium... 

Cowgill, C. R., and W. E. Anderson, "Laxative Effeas of Wheat Bran and Washed Bran in Heaithy Men. A comparative Study," Journal of the American Medical Association, Voi. 98, 1932, p. 1866. 

Finally, an intriguing possible future therapy arises from a radical idea of Horrobin (2001) that schizophrenia is a nutritional disorder linked to a decreased intake of essential polyunsaturated fatty acids. Recent 31P-MRS studies have shown changes in plasma membrane phospholipids in the neocortex of unmedicated schizophrenics, which would have deleterious consequences on synaptic neurotransmission (Fukuzako, 2001). A clinical trial with the co6 fatty acid derivative ethyleicosa-pentaenoic acid (LAX-101) in patients who had been unresponsive to clozapine, reported that a daily dose of 2g LAX-101 gave a 26% improvement in symptoms over 12 weeks compared with 6% with placebo (Peet and Horrobin, 2001). Maybe in... 

Gastrointestinal Effects. Minimal information is available on the gastrointestinal effects of human oral exposure to PAHs. In one study, humans that consumed anthracene-containing laxatives (the anthracene concentration was not specified) for prolonged periods of time were found to have an increased incidence of melanosis of the colon and rectum (i.e., unusual deposits of black pigments in the colon and rectum) compared to patients who did not consume anthracene laxatives. However, no definitive conclusions can be drawn from these results because of study limitations that include possible misclassification of patients with respect to the level of anthracene laxative use over 30 years and no accounting for other factors involved in the pathogenesis of melanosis (Badiali et al. 

Gastrointestinal Effects. Anthracene has been associated with gastrointestinal toxicity in humans. Humans that consumed laxatives that contained anthracene (anthracene concentration not specified) for prolonged periods were found to have an increased incidence (73.4%) of melanosis of the colon and rectum as compared to those who did not consume anthracene-containing laxatives (26.6%) (Badiali et al. 1985). The authors suggested that the melanosis observed may be attributed to the consumption of anthracene laxatives and not to intestinal stasis. This study is severely limited because of confounding factors such as the existence of other predisposing factors for melanosis and lack of follow-up. 

A meta-analysis to compare the efficacy of posterior internal anal sphincter (IAS) myectomy with intrasphinc-teric botulinum toxin injection for treatmenf of IAS achalasia involving 16 prospective and retrospective studies in a total of 395 patienfs [18 ] demonstrated no significant difference in continued use of laxatives or rectal... 

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