Laurencia majuscula, halogenated

Suzuki, M. and Kurosawa, E. 1978. Two new halogenated sesquiterpenes from the red alga Laurencia majuscula. Tetrahedron Lett. 4805-4808. 

The new red algal species Laurencia mariannensis from the Great Barrier Reef provides the novel sesquiterpene 297, along with the known pacifenol and deoxy-prepacifenol, which are now fully characterized by NMR for the first time (539). The Philippine Laurencia majuscula has furnished 13 novel halogenated sesquiterpenes 298-310, of which the major components are the majapolenes A (298, 299) (two diastereomers), which are also found in Laurencia caraibica (540). Most of these compounds occur as inseparable diastereomers. A collection of Laurencia majuscula from the South China Sea has yielded the cedrene-type sesquiterpene majusin (311) (541). A new sesquiterpene dichloroimine, stylotellane A (312), was isolated from the sponge Stylotella aurantium (Fig. 3.3) (542). 

Whereas Okinawan Laurencia cartilaginea and Laurencia concreta yielded no halogenated metabolites, Laurencia majuscula from these waters afforded (6/ ,9/ ,105)-10-bromo-9-hydroxychamigra-2,7(14)-diene (361) (577), which... 

Vairappan CS (2003) Potent Antibacterial Activity of Halogenated Metabolites from Malaysian Red Algae, Laurencia majuscula (Rhodomelaceae, Ceramiales). Biomol Engi-ner 20 255... 

Sheldrake HM, Jamieson C, Burton JW (2006) The Changing Faces of Halogenated Marine Natural Products. Total Synthesis of the Reported Structures of Elatenyne and an Enyne from Laurencia majuscula. Angew Chem Int Ed 45 7199... 

Diaz-Marrero, A.R., Brito, I., de la Rosa, J.M., Darias, J., and Cueto, M. (2008) Gomerones A-C, halogenated sesquiterpenoids with a novel carbon skeleton from Laurencia majuscula. Tetrahedron, 64, 10821-10824. 

Sheldrake, H.M., Jamieson, C., and Button, J.W. (2006) The changing face of halogenated marine natural products total synthesis of the reported structures of elatenyne and an enyne from Laurencia majuscula. Angew. Chem. Int. Ed., 45, 7199-7202. 

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