Laser microprobe mass spectrometry instrumentation

R. W. Odom and B. Schueler. Laser Microprobe Mass Spectrometry Ion and Neutral Analysis, in Lasers and Mass Spectrometry (D. M. Lubman, ed.) Oxford University Press, Oxford, 1990. Presents a useful discussion of LIMS instrumental issues, including the post-ablation ionization technique. Several anal)n ical applications are presented. 

Figure 2 Rationalization of the detected ions using the Dl model in LMMS by the effects of the (A) energy gradient created along the surface, (B) the pressure gradient in the selvedge, and (C) the time domain of ion formation and mass analysis. (Adapted from Van Vaeck L, Struyf H, Van Roy W, and Adams F (1994) Organic and inorganic analysis with laser microprobe mass spectrometry. Part I instrumentation and methodology. Mass Spectrometry Reviews 13 189-208 Wiley.)...

Laser microprobe mass spectrometry has been reviewed [47,328,331,334,337-339] Van Vaeck et al. [330] have discussed possibilities and limitations of LMMS. Darke et al. [53a] have reviewed the instrumental features. A monograph is available [130]. 

Van Vaeck L, Struyf H, Van Roy W and Adams F (1994) Organic and inorganic analysis with laser microprobe mass spectrometry. Part 1 Instrumentation and methodology. Mass Spectrometry Reviews 13 189- 209. 

Microprobe laser desorption laser ionisation mass spectrometry (/xL2MS) is used to provide spatial resolution and identification of organic molecules across a meteorite sample. Tracking the chemical composition across the surface of the meteorite requires a full mass spectrum to be measured every 10 p,m across the surface. The molecules must be desorbed from the surface with minimal disruption to their chemical structure to prevent fragmentation so that the mass spectrum consists principally of parent ions. Ideally, the conventional electron bombardment ionisation technique can be replaced with an ionisation that is selective to the carbonaceous species of interest to simplify the mass spectrum. Most information will be obtained if small samples are used so that sensitivity levels should be lower than attomolar (10—18 M) fewer than 1000 molecules can be detected and above all it must be certain that the molecules came from the sample and are not introduced by the instrument itself. 

Spengler, B. and Hubert, M. (2002) Scanning Microprobe Matrix-Assisted Laser Desorption Ionization (SMALDI) mass spectrometry instrumentation for sub-micrometer resolved LDI and MALDl surface analysis. J. Am. Soc. Mass Spectrom., 13, 735-748. 

See also Atomic Absorption Spectrometry Principles and Instrumentation Interferences and Background Correction. Atomic Mass Spectrometry Inductively Coupled Plasma Laser Microprobe. Liquid Chromatography Column Technology. 

See also Atomic Mass Spectrometry Laser Microprobe. Bioluminescence. Capillary Electrophoresis Overview. Chemometrics and Statistics Multivariate Calibration Techniques. Extraction Solvent Extraction Principles. Liquid Chromatography Overview Reversed Phase. Mass Spectrometry Principles. Phosphorescence Principles and Instrumentation Room-Temperature. 

See also Atomic Absorption Spectrometry Interferences and Background Correction. Atomic Emission Spectrometry Principles and Instrumentation Interferences and Background Correction Flame Photometry Inductively Coupled Plasma Microwave-Induced Plasma. Atomic Mass Spectrometry Inductively Coupled Plasma Laser Microprobe. Countercurrent Chromatography Solvent Extraction with a Helical Column. Derivatization of Analytes. Elemental Speciation Overview Practicalities and Instrumentation. Extraction Solvent Extraction Principles Solvent Extraction Multistage Countercurrent Distribution Microwave-Assisted Solvent Extraction Pressurized Fluid Extraction Solid-Phase Extraction Solid-Phase Microextraction. Gas Chromatography Ovenriew. Isotope Dilution Analysis. Liquid Chromatography Ovenriew. 

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