Larva migrans, drugs used

Several benzimidazoles are in use for the treatment of helminthic infections. Three of these, mebendazole, thiabendazole and albendazole, are described in this section. They have a broad range of activity against many nematode and cestode parasites, including cutaneous larva migrans, trichinosis, disseminated strongyloidiasis, and visceral larva migrans. A fourth, triclabendazole, is considered as the drug of choice for Easciola hepatica therapy. 

Clinical use Albendazole has a wide anthelmintic spectrum. It is an alternative drug for larva migrans, for ascariasis, and for infections caused by roundworms, whipworms, hookworms, pinworms, and threadworms. Albendazole is also active against the pork tapeworm in the larval stage. 

Clinical use Thiabendazole is a drug of choice for visceral forms of larva migrans and is an effective drug for treatment of strongyloidiasis, cutaneous larva migrans, and threadworm infections. Thiabendazole is rapidly absorbed from the gut and is metabolized by liver enzymes. The drug has anti-inflammatory and immunorestorative actions in the host. 

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