Lansium

In 1988, Furukawa et al. reported the isolation of 3-formylcarbazole (3) from the root bark of M. euchrestifolia (22). Three years later, McChesney and El-Feraly isolated 3-formylcarbazole (3), along with methyl carbazole-3-carboxylate (4), from the roots of Clausena lansium (23). The roots of this ornamental tree are used in traditional medicine in Taiwan to treat bronchitis and malaria (23). In 1992, Bhattacharyya et al. described the isolation and structural elucidation of 3-formylcarbazole (3) from G. pentaphylla (24). 

Methoxymurrayanine (3) (3-formyl-l,6-dimethoxycarbazole) (15) was isolated from the roots of C. lansium (23). The roots of C. lansium were used to treat bronchitis and malaria. The UV (/Imax 227, 239, 251, 294, 335, and 349 nm) and IR spectra showed the presence of a 3-formylcarbazole framework. The H-NMR data were similar to murrayanine (9), with an additional methoxy group for one of the aromatic hydrogens at the C-ring of the carbazole. Since the signal for H-5 (5 7.90) is not ortho-coupled, an additional methoxy could be located at C-6. This structural conclusion was also supported by the C-NMR spectrum. 

Since 1966, several carbazole alkaloids which are oxygenated at the C-iing were isolated from different natural sources. Glycozoline (86) was the first member of this class of alkaloids and was obtained from the stem bark of G. pentaphylla (95,96). In 1991, glycozoline (86) was also isolated by McChesney and El-Feraly from the roots of C. lansium (23). In Taiwan, the roots of this ornamental tree are used in traditional medicine for the treatment of bronchitis and malaria (23). In 1999, Chakravarty et al. isolated glycozoline (86) from the roots of G. arborea (62). 

O. nubilalis diets (Ewete etal., 1996b). We have also isolated nine triterpenes from bark of Lansium domesticum, collected in Borneo (Omar, 2000). These compounds, called lansiolides, including lansiolic acid (Fig. 1.4), have insect feeding-deterrent activity as well as antimalarial activity. 

Demethylnobiletin 6-Demethoxynobiletin 6-Demethoxytangeretin Sinensetin Tangeretin Cladonia macilenta Biruloquinone Clausena lansium Clausenamide Cnestis ferrupfi nea Amentoflavone Cnidium monnieri Osthole... 

LEATEMIA, J.A., ISMAN, M.B., Insecticidal activity of crude seed extracts of Annona spp., Lansium domesticum and Sandoricum koetjape against lepidopteran larvae, Phytoparasitica, 2004,32,30-37. 

Isolation and structural elucidation of -clausenamide, a benzo-fused lactam, were accomplished from the leaves of Clausena lansium <87GEP(0)3700706,9iMi 9i8-oi>. 

Maneerat W, Ritthiwigrom T, Cheenpracha S, Laphookhieo S. Carbazole alkaloids and coumarines from Clausena lansium roots. PkytochemLett 2012 5(l) 26-8. Manners GD, Panter KE, Ralphs MH, Pfister JA, Olsen JD, James LF. Toxicity and chemical phenology of norditerpenoid alkaloids in the tail Larkspurs Delphinium Species). J Agric Food Chem 1993 41 96-100. 

Julia-Colonna epoxidation in the synthesis of (+)-clausenamide (638). The y-lactam clausenamide (638) was isolated from the leaves of Clausena lansium, a species that is a liver-protecting Chinese folk medicine and is utilized also in cases of acute and chronic viral hepatitis (549). In their synthesis of 638, Roberts et al. employed a fixed-bed poly-L-leucine catalyst together with DABCO-H2O2 as the oxidant to carry out an early-stage epoxidation of chalcone 639 to obtain epoxide 640 in high enantiomeric excess (>98% ee) (Scheme 132). After five more steps, the total synthesis of (+)-clausenamide (638) was accomplished in an overall yield of 40% (547). 

Lansium domesticum (family Meliaceae) Commonly known as langsat and distributed in South-East Asia it is reputed to be one of the best fruits of Malaysia. The juicy aril is the edible part, which is sweet and eaten raw. 

Taxonomy Cycloartane Tiiterpenoids Lansium domesticum (Meliaceae) [1],... 

Constit. of leaves of Lansium domesticum. Skin tumour inhibitor. Cryst. Mp 185-186°. [a]] -1-18.7° (c, 1.16 in CHCI3). 

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