Clausena lansium

In 1988, Furukawa et al. reported the isolation of 3-formylcarbazole (3) from the root bark of M. euchrestifolia (22). Three years later, McChesney and El-Feraly isolated 3-formylcarbazole (3), along with methyl carbazole-3-carboxylate (4), from the roots of Clausena lansium (23). The roots of this ornamental tree are used in traditional medicine in Taiwan to treat bronchitis and malaria (23). In 1992, Bhattacharyya et al. described the isolation and structural elucidation of 3-formylcarbazole (3) from G. pentaphylla (24). 

Demethylnobiletin 6-Demethoxynobiletin 6-Demethoxytangeretin Sinensetin Tangeretin Cladonia macilenta Biruloquinone Clausena lansium Clausenamide Cnestis ferrupfi nea Amentoflavone Cnidium monnieri Osthole... 

Isolation and structural elucidation of -clausenamide, a benzo-fused lactam, were accomplished from the leaves of Clausena lansium <87GEP(0)3700706,9iMi 9i8-oi>. 

Maneerat W, Ritthiwigrom T, Cheenpracha S, Laphookhieo S. Carbazole alkaloids and coumarines from Clausena lansium roots. PkytochemLett 2012 5(l) 26-8. Manners GD, Panter KE, Ralphs MH, Pfister JA, Olsen JD, James LF. Toxicity and chemical phenology of norditerpenoid alkaloids in the tail Larkspurs Delphinium Species). J Agric Food Chem 1993 41 96-100. 

Julia-Colonna epoxidation in the synthesis of (+)-clausenamide (638). The y-lactam clausenamide (638) was isolated from the leaves of Clausena lansium, a species that is a liver-protecting Chinese folk medicine and is utilized also in cases of acute and chronic viral hepatitis (549). In their synthesis of 638, Roberts et al. employed a fixed-bed poly-L-leucine catalyst together with DABCO-H2O2 as the oxidant to carry out an early-stage epoxidation of chalcone 639 to obtain epoxide 640 in high enantiomeric excess (>98% ee) (Scheme 132). After five more steps, the total synthesis of (+)-clausenamide (638) was accomplished in an overall yield of 40% (547). 

Figures in the bracket represent the plant source specified here 1 Murraya koenigii Spreng., 2. M. paniculata L. Jack (Syn. M. exotica Linn.), 3. M. euchrestifolia Hyata., 4. Glycosmis penta-phylla (Retz) D.C., 5. Clausena anisata (Willd) Olive., 6. C. heptaphylla Wt. Arn., 7. C. indica Olive., 8. C. lansium (Lour.) Skeels (Syn. C. wampi Olive.), 9. Micromelum zelynicum, 10. Ekebergia senegalensis.

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