Clausena lansium Clausenamide

Demethylnobiletin 6-Demethoxynobiletin 6-Demethoxytangeretin Sinensetin Tangeretin Cladonia macilenta Biruloquinone Clausena lansium Clausenamide Cnestis ferrupfi nea Amentoflavone Cnidium monnieri Osthole... 

Isolation and structural elucidation of -clausenamide, a benzo-fused lactam, were accomplished from the leaves of Clausena lansium <87GEP(0)3700706,9iMi 9i8-oi>. 

Julia-Colonna epoxidation in the synthesis of (+)-clausenamide (638). The y-lactam clausenamide (638) was isolated from the leaves of Clausena lansium, a species that is a liver-protecting Chinese folk medicine and is utilized also in cases of acute and chronic viral hepatitis (549). In their synthesis of 638, Roberts et al. employed a fixed-bed poly-L-leucine catalyst together with DABCO-H2O2 as the oxidant to carry out an early-stage epoxidation of chalcone 639 to obtain epoxide 640 in high enantiomeric excess (>98% ee) (Scheme 132). After five more steps, the total synthesis of (+)-clausenamide (638) was accomplished in an overall yield of 40% (547). 

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