Children zonisamide

Dosing and Administration. In adults, the initial recommended dose of zonisamide is 100 mg/day. Doses should be titrated by 100 mg daily every 2 weeks to patient response. The dosage range in adults is 100 to 600 mg/day. In children, zonisamide can be initiated at a dose of 2-4 mg/kg per day and titrated to 4-8 mg/kg per day up to a maximum of 12 mg/kg per day. Zonisamide is stable for 48 hours when mixed with water, apple juice, or pudding for patients who have trouble swallowing oral solid dosage forms. 

Leppik IE. Three new drugs for epilepsy levefiracefam, oxcarbazepine, and zonisamide. J Child Neurol. 2002 f7 SuppI f S53-7. 

GlauserTA, Pellock JM. Zonisamide in pediatric epilepsy review of the Japanese experience. J Child Neurol. 2002 f 7 87-96. 

Zonisamide-induced lupus erythematosus has been reported in a 5-year-old child taking zonisamide and etho-suximide (15). He had raised titers of antinuclear antibodies and anti-DNA antibodies and presented with fever, pericarditis, pleurisy, and arthralgia. Clinical recovery and a reduction in the anti-DNA-antibody titer promptly followed withdrawal. A lymphocyte transformation test against zonisamide was positive. 

Shimizu T, Yamashita Y, Satoi M, Togo A, Wada N, Matsuishi T, Ohnishi A, Kato H. Heat stroke-like episode in a child caused by zonisamide. Brain Dev 1997 19(5) 366-8. 

Metabolism Possible zonisamide-induced hyperammonemia occurred in a child with citrullinemia [446 ]. Inhibition of carbonic anhydrase by zonisamide, which in turn reduces the availability of bicarbonate ions for carbamylphosphate synthesis, was the suggested mechanism. 

---

See also in sourсe #XX -- [ ]

---