Tiagabine topiramate

Vigabatrin (not marketed in United States), tiagabine, topiramate, gabapentin, carbamazepine, lamotrigine... 

Carbamazepine, phenytoin, valproate, gabapentin, lamotrigine, levetiracetam, tiagabine, topiramate, zonisamide... 

U.K. guidelines Tiagabine Topiramate Zonisamide Children Gabapentin Lamotrigine Oxcarbazepine Topiramate Gabapentin ... 

Lamotrigine Levetiracetam Oxcarbazepine Tiagabine Topiramate Generalized seizures absence (newly diagnosed) ... 

II.e. 5.2. Interactions between first and second generation AEDs. Felbamate raises plasma concentrations of phenytoin, valproic acid and carbamazepine. Clearance of tiagabine, topiramate and zon-isamide is increased in the presence of an enzyme inducer. Vigabatrin reduces phenytoin concentrations after 4-5 weeks of comedication (via an unknown mechanism). For tiagabine, the elimination half-life may be reduced by 2-3 hours in the presence of an enzyme-induction AED. Lamotrigine elimination is slower if given with valproic acid. Topiramate reduces elimination of phenytoin. 

For simple and complex partial seizures and secondary generalized tonic-clonic seizures, the first line drugs are - carbamazepine, valproate and phenytoin. Second line drugs include - acetazolamide, clobazam, clonazepam, ethosuximide, felbamate, gabapentin, lamotrigine, levetiracetam, oxacarbamazepine, primidone, tiagabine, topiramate and vigabactin. 

See pp. 445-446 for a description of the newly approved drugs, tiagabine, topiramate and vigabatin. 

Carbamazepine can decrease piasma ieveis of acetaminophen, ciozapine, benzodiazepines, dicumaroi, doxycyciine, theophyiiine, warfarin, and haioperidoi as weii as other anticonvuisants such as phensuximide, methsuximide, ethosuximide, phenytoin, tiagabine, topiramate, iamotrigine, and vaiproate... 

There are minimal or no efficacy data for some adjunctive (add-on) therapies az-adrenergic agonists, calcium channel blockers, gabapentin, tiagabine, topiramate, and zonisamide topiramate may have efficacy as an adjunctive agent with standard agents for maintenance therapy, based on initial trials. 

The place in therapy of the newer anticonvulsants, such as gabapentin, levetiracetam, tiagabine, topiramate, and zon-isamide, is controversial. Many clinicians consider these agents to be less effective than established mood stabilizers based on initial studies and avoid them for monotherapy in bipolar disorder. 

Table IV-1 -3 summarizes the mechanisms, indications for use, and potential toxic effects of some i newer anticonvulsants. Those listed are felbamate, gabapentin, lamotrigine, tiagabine, topiramate, and j...

Complex partial Partial with secondarily Impaired consciousness lasting 30 seconds to 2 minutes, often associated with purposeless movements such as lip smacking or hand wringing. Simple or complex partial seizure evolves into a Carbamazepine, phenytoin, valproate Gabapentin, lamotrigine, levetiracetam, tiagabine, topiramate, zonisamide... 

---