Lactase secondary

There are several forms of intolerance to lactose and galactose. Primary adult lactase deficiency is a normal age-related decrease in lactase activity seen in the majority of adults. Secondary lactase deficiency is a transient state of low enzyme activity following injury to the intestinal mucosa as a result of diseases such as celiac sprue, infectious gastroenteritis, and protein-calorie malnutrition. The last two states are common conditions (Dahlqvist 1983). 

Sucrase-isomaltase deficiency usually presents clinically in infancy when sucrose and fruit are introduced in the diet, " but sometimes first presents in adulthood. The deficiency is rare in Caucasians, but more common in Eskimo groups. Deficiencies of both lactase and sucrase-isomaltase may occur secondary to other small bowel diseases (e.g., cehac disease, Crohn s disease,or acute gastroenteritis). Trehalase deficiency is a rare disorder,except in Greenland, where it occurs in 8% of the population. It is manifested by diarrhea following the ingestion of mushrooms. 

Lactase enzyme products are helpful for patients experiencing diarrhea secondary to lactose intolerance. Lactase is required for... 

Intestinal diseases that injure the absorptive cells of the intestinal villi diminish lactase activity along the intestine, producing a condition known as secondary lactase deficiency. Kwashiorkor (protein malnutrition), colitis, gastroenteritis, tropical and... 

Lactose intolerance can either be the result of a primary deficiency of lactase production in the small bowel (as is the case for Deria Voider) or it can be secondary to an injury to the intestinal mucosa, where lactase is normally produced. The lactose that is not absorbed is converted by colonic bacteria to lactic acid, methane gas (CH4), and Hj gas (see figure on left). The osmotic effect of the lactose and lactic acid in the bowel lumen is responsible for the diarrhea often seen as part of this syndrome. Similar symptoms can result from sensitivity to milk proteins (milk intolerance) or from the malabsorption of other dietary sugars. 

Lactase is iocated in the brush border (microviiii) of small intestinal enterocytes. Lactase deficiency can be primary, secondary or rarely, congenital. Dietary lactose accumulates causing flatulence and diarrhoea. 

Biofermented yoghurt contains a higher lactose content than fresh milk d. True lactase deficiency can be confirmed by the hydrogen breath test c. Temporary secondary lactose intolerance may occur after a severe gastrointestinal infection... 

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