Laboratory screening performance

Using physical properties relating to performance parameters leads to the development of algorithms for predicting performance for laboratory screening of potential improvements. Many of these algorithms have been estabUshed. The two main categories of measurement criteria are quasi static and dynamic mechanical properties. 

McCormick, C.L., et al. "Development of Laboratory Screening Tests to Predict Polymer Performance in Enhanced Oil Recovery (I). Shear Degradation, Viscosity, and Electrolyte Studies," prepared for DOE under contract No. EF-77-S-05-5603, 1977. 

Enzyme immunoassay kits are now available for qualitative field testing or for laboratory screening and semiquantitative analysis of pesticides, herbicides, polychlorinated biphenyls (PCBs), mononuclear and polynuclear aromatic hydrocarbons, pentachlorophenol, nitroorganics, and many other compounds in aqueous and soil samples. Certain analytes may be quantitatively determined as well, with a degree of accuracy comparable to gas chromatography or high performance liquid chromatography determination. The method is rapid and inexpensive. 

A series of laboratory screening tests were performed to evaluate the influence of the nine independent variables. To reduce the required number of screening tests, a fractional factorial experimental design was made using high and low values of the nine variables listed. A one-eighth factorial was sufficient to determine the combination of variables needed to evaluate their influence on the mixture. 

Sources of imprecision in laboratories screening for congenital hypothyroidism Analysis of nine years of performance data. Clin Chem 1989 35 1701-5. 

A recently developed computer-based technique allows time spent in laboratory screening of solvent formulations for particular applications to be greatly reduced (I). In this method, blend performance properties are calculated by simple mixing rules from the properties of the component solvents, and a blend composition is chosen which will match a required set of properties while minimizing cost. Solvent blends formulated in this way have an excellent chance of success in subsequent laboratory tests. 

Before implementing electrokinetics, it is necessary to find if the site conditions match the requirements necessary for the successful performance of the technology. This can be done by a number of field and laboratory screening tests ... 

Axin is a concentration-limiting factor for the formation of the p-catenin destruction complex [8]. Mathematical modeling suggests that the most efficient way to inhibit Wnt signaling is to increase the concentration of Axin [8]. Consistent with this prediction, the most potent and specific inhibitors from Wnt reporter screens performed in different laboratories are all Axin stabilizers and TNKS inhibitors [22, 25, 32]. Therefore, TNKS inhibition represents the most robust and tractable mechanism to inhibit Wnt signaling. 

Although immunoassays and other screening techniques may be very sensitive for some benzodiazepines, they may not provide enough cross-reactivity for detecting the wide variety of benzodiazepines available today in the United States, and abroad (1). Laboratories that perform analysis of benzodiazepines for DFSA cases should validate their procedures to ensure that their method is capable of detecting benzodiazepines in accordance with the guidelines established by the Society of Forensic Toxicologists (SOFT) DFSA Committee (2). The benzodiazepine detection limits... 

S.E. Jewell, W.J. Slazyk, S.J. Smith, and W.H. Hannon, Sources of Imprecision in laboratories screening for congenital hypothyroidism analysis of nine years of performance data, Clin Chem 35(8) 1701-1705(1989). 

Wheat straw was obtained from Silsoe Research Institute (Silsoe, Bedfordshire, UK), and was dried in a cabinet oven with air circulation at bO C for 16 h. The dried wheat straw was then ground using a Christie Laboratory mill to pass a 60-mesh size screen and stored at 5°C until use. All chemicals were of analytical or regent grade. All experiments were performed in duplicate and yield is given on a dry wheat straw weight basis. 

Felcht reports that the testing of industrial-scale processes can be performed with low expenditure by using micro reactors, since this should result in a faster time to market of the development [137]. He also sees uses for micro reactors at the laboratory scale as a means of high-throughput screening and model examinations such as fast determination of reaction kinetics. 

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