Laboratory medicine testing programs

The approaches to analytical procedures uncertainty prognosis are developed. The correctness of these approaches is confirmed in 3rd and 4th rounds of pharmaceutical laboratories inter-laboratory testing ( Phamia-Test program of State Inspection for Quality Control of Medicines, Ministry of Health of Ukraine). 

Finally, it is apparent that the field of medicine is moving toward the acceptance of and active pursuance of preventive medicine. The use of multiphasic screening laboratories is becoming more widespread to achieve this end. In such programs, the aim is to detect incipient diseases so they can be treated prior to the need for expensive hospitalization. So far, many of the tests and techniques used in these facilities have been adapted from the clinical laboratory that operates in the hospital where acutely sick patients are present. It is obvious that as we gain more knowledge of the chemical indicators of disease, tests that are more definitive for these indicators must be developed. High-resolution systems seem uniquely suitable to such a task as they become truly economic systems. 

Traversianal, though not dothistromin, was also tested for toxicity to snail (Biomphalaria sp ) and was found to be unusually toxic, causing 100% mortality at 3 2 x 10" M (10 p p m ) and 25% at 3.2 x 10 6 M. This activity level is equal to or greater than that observed for helenalin, the most active of several compounds tested previously in the UBC laboratory (38), as part of a program on potentially medicinally useful natural products Molluscicides, particularly naturally occurring ones (39), are of much current interest as agents for the control of snails as vectors of schistosomiasis (40). 

To assure the accuracy and comparabihty of the results with other laboratories, an appropriate external quality assessment is necessary. For external quality control, participation in a round robin test is recommended. There are various quality control programs containing cadmium in blood and urine, e.g., the international program of the German External QuaUty Assessment Scheme (E-QUAS), where cadmium analysis can be tested for the concentration range found in occupational and environmental medicine [48], or the external quahty assessment schemes of the Centre of Toxicology in the National Institute of Public Health of Quebec [49]. 

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