8,19-Epoxy-l

Similarly, reaction of 2-nitroimidazole with l,2-epoxy-3-methoxypropane in the presence of potassium carbonate gives misonidazole This agent also has the interesting and... 

Penz, G. and Zbiral, E., Zur Synthese von (rac)-czs-l,2-Epoxy-3-oxo-alkyl-phosphonsaureestern Phosphonomycinanaloga, Monatsh. Chem., 113, 1169, 1982. 

Although the Payne rearrangement usually produces mixtures of epoxy alcohols, because the rate of reaction of 2 with any given nucleophile is faster than that of i, the l,2-epoxy-3-alcohols generated in situ can be selectively and irreversibly captured by a nucleophile to afford 3. 

Synonyms AGE AI3-37791 AllyE2,3-epoxypropyl ether l-Allyloxy-2,3-epoxypropane BRN 0105871 CCRIS 2375 EINECS 203-442-4 l,2-Epoxy-3-allyloxypropane Glycidyl allyl ether M 560 NC1-C56666 NSC 18596 [(2-Propenyloxy)methyl]oxirane UN 2219. 

Synonyms AI3-03545 BRN 0079785 Caswell No. 424 CCRIS 277 l-Chloro-2,3-epoxypro-pane 3-Chloro-l,2-epoxypropane (Chloromethyl)ethylene oxide (Chloromethyl)oxirane 2-(Chloromethyl)oxirane 2-Chloropropylene oxide y-Chloropropylene oxide 3-Chloro-l,2-propyl-ene oxide ECH EINECS 203-439-8 EPA pesticide chemical code 097201 a-Epichlorohydrin (d -a-Epichlorohydrin Epichlorophydrin l,2-Epoxy-3-chloropropane 2,3-Epoxy propyl chloride Glycerol epichlorohydrin NCI-C07001 NSC 6747 RCRA waste number U041 UN 2023. 

Synonyms AI3-50540 Allyl alcohol oxide BRN 0383562 CCRIS 1052 EINECS 209-128-3 Epihydric alcohol Epihydrin alcohol l,2-Epoxy-3-hydroxypropane 2,3-Epoxypropanol 2,3-Epoxy-1-propanol Epoxypropyl alcohol Glycide Glycidyl alcohol l-Hydroxy-2,3-epoxy-propane Hydroxymethyl ethylene oxide 2-Hydroxymethyloxiran 3-Hydroxypropylene oxide NCI-C55549 NSC-C55549 Oxiranemethanol Oxiranylmethanol UN 2810. 

An alternative synthetic method for preparing chiral l,2-epoxy-3-alkanol tosylates using Sharpless AD reaction as the key step has been reported and was used in the total synthesis of two insect pheromones namely,... 

Metoprolol Metoprolol, l-(wo-propylamino)-3-[4 (2-methoxyethyl)phenoxy]-2-propanol (12.1.5), is synthesized by reacting 4-(2-methoxyethyl)phenol with epichlorhy-dride in the presence of a base, isolating l,2-epoxy-3-[4 (2-methoxyethyl)phenoxy] propane (12.1.4), the subsequent reaction of which, analogous to that described before, with jio-propylamine, gives an opening of the epoxide ring and leads to the formation of metoprolol (12.1.5) [7,8]. 

Synonyms Allyl alcohol oxide epihydrin alcohol l,2-epoxy-3-hydroxypropane 2,3-epoxy-l-propanol ( )-2,3-epoxy-1-propanol glycide ( )-glycidol (RS)-glycidol dl-glycidol glycidyl alcohol hydroxy-l,2-epoxypropane l-hydroxy-2,3-epoxypropane 2-(hydroxymethyl)oxirane 3-hydroxypropylene oxide oxiranyl-methanol racemic glycidol... 

Butadiene is metabolized in experimental animals and human liver microsomes to epoxide metabolites, initially l,2-epoxy-3-butene and subsequently 1,2 3,4-... 

Seaton, M.J., Follansbee, M.H. Bond, J.A. (1995) Oxidation of l,2-epoxy-3-butene to 1,2 3,4-diepoxybutane by cDNA-expressed human cytochromes P450 2E1 and 3A4 and human, mouse and rat liver microsomes. Carcinogenesis, 16, 2287-2293... 

Sjoblom, T. Lahdetie, J. (1996) Micronuclei are induced in rat spermatids in vitro by 1,2,3,4-diepoxybutane but not by l,2-epoxy-3-butene and 1.2-dihydroxy-3,4-epoxybutane. Mutagenesis, 11, 525-528... 

Uuskula, M., Jarventaus, H., Hirvonen, A., Sorsa, M. Norppa, H. (1995) Influence of GSTMl genotype on sister chromatid exchange induction by styrene-7,8-oxide and l,2-epoxy-3-butene in cultured human lymphocytes. Carcinogenesis, 16, 947-950... 

Where a very stable oarbonium ion is possible, bridged intermediates are less likely to participate in epoxide isomerization. With 2-feri-butyl-l,2-epoxy-3,3-dimethylbutane no lees than Beven prmLuclK are farmed, according to Newman and oo-workera.IW7 These presumably ariee from the initially generated di-ferf-butylcarboruim ion. The chief product, ieolable in 40-60% yield, is 2-f rt-butvl-J>3-dimetbyl-3-buten-l-ol (Eq. 430). 

Petrov1 , ws hag described the cleavage of 4-bromo- l,-epoxy-S-butene and 8-bromo-l,2-epoxy-3-butene (Eq. 711) villi bydrobromic acjd, which allegedly gives primary alcohols os above. 

Condensation gf phenyl isocyanate has also been reported reoently 88 to occur with phonyl glycidyl other and l,2-epoxy-3-phenylhutane in the presence of catalytic amounts of benzyldimethyl-amine (Eq. 973). 

Reduction of 1,2-cpoxy-3-butene over Raney nickol ut 76° gives t-butanol, whereas palladium on charcoal merely causes reduction of tlie double bond and isomerization to a-butyraldehyde7 (Eq. 343). Reduction of 3-chloro-l,2-epoxy-3-buteue over palladium cm calcium... 

Albitekaya and co-worfcere201 observed the formation of both poauble products, however, when 3-ohlQro-l,2-epoxy 3-buteoe was... 

Similarly, Petrov1 has repented addition of hydrogen bromide to l,2-epoxy-3-pentyne (Eq. 712), which gives rise to 2-bromo-3-pentyn-l-ol exclusively, Thu and related results are doubtless attributable to the ability of double and triple bonds to stabilize partial oarboniuin ion character development in the borderline 8 i2 transition state.1 ... 

Cyclohexene oxidation in the presence of the vanadium complex, [C5H5V(CO)4], gave a product distribution which differed greatly from that observed with either the iron or the molybdenum complex. The major product, l,2-epoxy-3-hydroxycyclohexane, IX, was not formed with the iron or molybdenum complexes. The epoxy alcohol, IX, represented... 

Synonyms l,2-epoxy-3-chloropropane 2-(chloromethyl)oxirane 2,3-epoxy-propyl chloride Formula C3H5C10 Structure ... 

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