L1210 leukemia cell

However, similar changes in hpid conposition are possible using a variety of other cell types (Bums and Wagner, 1993) such as an adenocarcinoma (Awad and Specter, 1976), and hepatoma (Wood et al, 1975). The dietary fatty acid modification is not limited to tumor cells, since many tissues of the host are affected (Bums et al., 1983). However, different tissues are modified to varying extents, and because of this it will likely be possible to develop protocols that provide therapeuhc selechvity by producing greater or lesser enrichment of the neoplashc cells with a particular type of fatty acid as compared to normal tissues. We have also demonstrated that L1210 leukemia cells that were fatty acid modified in vivo and then placed into tissue culture maintain their experimentally-induced fatty acid composition for up to 4 days (Bums et al, 1980). Therefore, this is a versahle model. 

The complex [Ru(tpy)Cl3] binds to DNA, and is active as a cytostatic in L1210 leukemia cells. Its activity lies between those of cisplatin and carboplatin. Model complexes [Ru(tpy)L(H20)] + in which L = 9-ethylguanine or 9-methylhypoxanthine, have been prepared and characterized using NMR spectroscopy. " Proton NMR spectroscopy has been applied to a study of hydrogen bonding between 2, 3 -isopropylidine adenosine and [Ru(tpy)2] derivatives bearing a thymine group. 

Hromas RA, North JA, Burns CP. Decreased cisplatin uptake by resistant L1210 leukemia cells. 

Also, the interaction of these nucleosides with cellular constituents of intact L1210 leukemia cells was studied.76 Rapid reaction with plasma membrane and soluble, intracellular thiols was demonstrated, as well as a good correlation between the extent of plasma membrane alkylation in vitro and the biological activity in vivo. 

The dibenzo[l,2,5]thiadiazepines 443 and 444 have been tested for their antiproliferative activity against the L1210 leukemia cell line. Both compounds display low cytotoxicity with IC50 values of 12.7 and 29.9 pM, respectively <2004H(63)2457>. 

Baurain, R., M. Masquelier, D. Deprez-De Campeneere, and A. Trouet. 1980. Amino acid and dipeptide derivatives of daunorubicin. 2. Cellular pharmacology and antitumor activity on L1210 leukemia cells in vitro andin vivo. J. Med. Chem23 1171-1174. 

Grossularins I (37) and II (38), the first examples of naturally occurring a-carbolines, were obtained from a French solitary tunicate (Dendrodoa grossularia) and were found to be cytotoxic toward L1210 leukemia cells (55). Previously the structure of grossularin I was proposed as 39 (56), which was revised to 37 on the basis of comparison with the structure of grossularin II (38). Structural proof for 38 was unambiguously provided by X-ray analysis. The same tunicate contained 3-indolyl-4//-imidazol-4-one (40), the structure of which was confirmed by synthesis (57). The imidazo-lone compound (40) was devoid of cytotoxicity. 

Nuclei of mouse L1210 leukemia cells DNA fragmentation No data - Fornance et al. 1981 Potassium chromate... 

Pt-NMR chemical shifts in the -3000 ppm region, indicative of a [N3S] mixed-donor environment of platinum, confirm the monofunctional nature of the above Pt-nucleobase adducts. This ultimately prevents the formation of a bifunctional (cytotoxic) lesion on target DNA, in accordance with the lack of in vitro cytotoxicity found in L1210 leukemia cells (7DW >... 

Bums, C. P., Haugstad, B. N., and North, J. A., 1987, Membrane transport ofmitoxantrone by L1210 leukemia cells, Biochem. Pharmacol. 36 857-860. 

Burger and Goldberg30 first reported that, of the sugars found in glycoproteins, only 2-acetamido-2-deoxy-D-glucose andN,]V -diacetyl-chitobiose inhibited the agglutination of polyoma virus-transformed BHK cells and chemically-induced L1210 leukemia cells (compare Refs. 501-504). 

Mouse L1210 leukemia cells were the source of a fraction containing wheat-germ-agglutinin-reactive glycoproteins.884-868 Insoluble... 

Diplamine Cytotoxic toward L1210 leukemia cells 0.002 g/ml 189... 

Table 1 Growth Inhibitory Activity of GlcN and GalN Analogs Against Erlich and L1210 Leukemia Cells...

The synthesis of a number of benzo[b][l,7]phenanthroline anticancer agents from 10-aminobenzo[b][l,7]phenanothroline 64 has been claimed (91MIP1). Thus, ll-formyl-10-hydroxybenzo[h][l,7]phenanthroline 66 exhibited cytotoxicity, with an IC50 of 6.5 fiM, against L1210 leukemia cells. 

These compounds are inferior to pyrazofurin [97AHC(68)223] as antitumor agents against P388 and L1210 leukemia cells or Lewis lung carcinoma (85JOC1741) (Scheme 148). 

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