Krebs, Sir Hans

Krebs, Sir Hans Adolf (1900-1981) German/British Biochemist Sir Hans Adolf Krebs was born at Hildesheim, Germany, on August 25, 1900, to Georg Krebs, M.D., an ear, nose, and throat surgeon of that city, and his wife Alma (nee Davidson). 

Krebs, Sir Hans Adolf (1900-81) German-born British biochemist, who emigrated to Britain in 1933, working at Sheffield University before moving to Oxford in 1954. Krebs is best known for the Krebs cycle, the basis of which he discovered in 1937. Details were later added by Fritz Lipmann (1899-1986), with whom Krebs shared the 1953 Nobel Prize for physiology or medicine. 

Krebs, Sir Hans Adolf (1900-81) German-born British biochemist... 

Krebs, (Sir) Hans Adolf (1900-81) German-born British biochemist renowned for his work on metabolism and, in particular, for the discovery of the cyclic metabolic pathways named after him. He was awarded the Nobel Prize for physiology or medicine in 1953 for his discovery of the TCA cycle. The prize was shared with F. A. Lipmann. 

Drs. Mary Gale, Brian Lloyd, and the late Hugh Sinclair helped us with references to early studies on nutrition Mr. Reg Hems and Dr. Dereck Williamson recounted their memories of working with Sir Hans Krebs and Dr. F. L. Holmes very kindly allowed us to read in manuscript the first volume of his authoritative work on Krebs. The late Professors Bill Paton and David Whitteridge directed us to important references in the history of physiology. Professor Bradford, the... 

Perutz, M. F. X-ray analysis, structure and function of enzymes (The First Sir Hans Krebs Lecture). European J. Biochem. 8, 455—466 (1969). 

Cohen, P. (2001) The role of protein phosphorylation in human health and disease the Sir Hans Krebs Medal Lecture. Eur. J. Biochem. 268, 5001-5010. 

Brosnan, J.T. (2001) Amino acids, then and now—a reflection on Sir Hans Krebs contribution to nitrogen metabolism. IUBMB Life 52, 265-270. 

Sir Hans Adolf Krebs (1900-1981) was born in Hildesheim, Germany, and received an M.D. in 1925 from the University of Hamburg. In 1933 he moved to England, first at the University of Cambridge, then at the University of Sheffield (1935-1954), and finally at the University of Oxford (1954-1967). He received the 1953 Nobel Prize in medicine for his work on elucidating pathways in intermediary metabolism. 

Krebs cycle A biochemical cycle in the second stage of cellular respiration involving eight steps that complete the metabolic breakdown of glucose molecules to carbon dioxide. Acetyl CoA is combined with oxaloac-etate to form citric acid. Citric acid is then converted into a number of other chemicals, and carbon dioxide is released. The process takes place within the mitochondrion. Also called citric acid cycle or tricarboxylic acid (TCA) cycle. Conceived and published by British scientist Sir Hans Adolf Krebs in 1957. 

The following are mainly for historical researchers. It would not be complete without reading about Sir Hans Krebs and his founding contributions to modern biochemistry. Volume 1 is about his early life, so volume 2 is a better choice for reading about his methods and the conclusions that stand today regarding the core of metabolism of most living things. 

This pathway is often referred to as the Krebs cycle in honor of Sir Hans Krebs who worked out the steps of this cyclic pathway from his own experimental data and that of other researchers. It is also called the tricarboxylic acid (TCA) cycle because several of the early intermediates in the pathway have three carboxyl groups. 

The citric acid cycle is sometimes called the Krebs cycle, in honor of its discoverer. Sir Hans Krebs. It is the final stage of the breakdown of carbohydrates, fats, and amino acids released from dietary proteins (Figure 22.5). 

British biochemist Sir Hans Adoif Krebs, corecipient of the 1953 Nobei Prize in physioiogy or medicine, for his discovery of co-enzyme A and its importance for intermediary metaboiism. ... 

The TCA cycle is frequently called the Krebs cycle because Sir Hans Krebs first formulated its reactions into a cycle. It is also called the "citric acid cycle" because citrate was one of the first compounds known to participate. The most common name for this pathway, the tricarboxylic acid or TCA cycle, denotes the involvement of the tricarboxylates citrate and isocitrate. 

The citric acid cycle has two other common names. One is the Krebs cycle, after Sir Hans Krebs, who first investigated the pathway (work for which he received a Nobel Prize in 1953). The other name is the tricarboxylic acid cycle (or TCA cycle), from the fact that some of the molecules involved are acids with three carboxyl groups. We shall start our discussion with a general overview of the pathway and then go on to discuss specific reactions. 

Stage in in the oxidation of fnel molecnles (Section 12.6) begins when the two-carbon acetyl units (of acetyl CoA) enter the citric acid cycle. This process is called the citric acid cycle because one of the key intermediates is citric acid. However, it is also called the tricarboxylic acid cycle (TCA) in reference to the three carboxylic acid groups in citric acid, and the Krebs cycle in honor of Sir Hans A. Krebs, who deduced its reaction sequence in 1937 (see h Figure 13.6). 

Acetyl CoA can be derived from carbohydrates (via glycolysis), fats, or certain amino acids. (Other amino acids may enter the cycle at different stages.) Thus the Krebs cycle is the central crossroads in the complex system of metabolic pathways and is involved not only in degradation and energy production but also in the synthesis of bio-molecules. It is named after its principal discoverer, Sir Hans Krebs. 

---