Knowledge base, continued Information

The author and the publisher of this Work have made every effort to use sources believed to be reliable to provide information that is accurate and compatible with the standards generally accepted at the time of publication. Because medical science is continually advancing, our knowledge base continues to expand. Therefore, as new information becomes available, changes in procedures become necessary. We recommend that the reader always consult current research and specific institutional policies before performing any clinical procedure. 

Knowledge-based methods can clearly provide valuable predictive information and will become increasingly powerful as the quantity of relevant data (i.e., the number of known crystal structures) increases. These methods are not an alternative to the continued development of lattice-energy-based methods, but are complementary methods that provide further information that can be used to assess the likely crystal forms of a molecule. 

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