Metabolism kinetics

W. Liebermeister and E. Klipp, Bringing metabolic networks to life Integration of kinetic, metabolic, and proteomic data. Theor. Biol. Med Modeling 3(42), (2006). 

A term used to refer to any chemical process whose rate depends upon saturation of a binding site. Rate saturation is observed in enzyme kinetics, metabolic... 

Greenblatt DJ, von Moltke LL, Harmatz JS, et al Human cytochromes and some newer antidepressants kinetics, metabolism, and drug interactions. J Clin Psychopharmacol 19 23S-35S, 1999 Karliova M, Treichel U, Malago M, et al Interaction of Hypericum perforatum (St. John s wort) with cyclosporin A metabolism in a patient after liver transplantation. J Hepatol 33 853-855, 2000 Michalets EL Update clinically significant cytochrome P-450 drug interactions. Pharmacotherapy 18 84-112, 1998... 

Greenblatt DJ, von Moltke LL, Harmatz JS, et al. Human cytochromes and some newer antidepressants kinetics, metabolism, and drug interactions. J Clin Psychopharmacol 1999 19 23S-35S. 

Highlighted the kinetic, metabolic, exposure, and toxicity differences of a preformed or synthetic metabolitefs) compared to that... 

Ten of the 20 pesticides known to be teratogenic (Table 20) in animals are OPPs (starred). None is listed for teratologic studies in the latest published NTP Annual Plan and NTP Review of the National Toxicology Program (1986). A few, including Parathion are scheduled for neuro-behavioral, and/or pharmaco-kinetic/metabolism studies, but at relatively low (D) priority (ref. 172a,b). 

The determination of total PCT by MS is a difficult procedure in which errors can easily be made. Chemical transformations in the environment, biological availability, uptake kinetics, metabolism, and elimination from organisms will... 

Chloroform is assumed to be metabolized in either the liver or the kidney, and the rates of biotransformation in these tissue are described by Michaelis-Menten kinetics. Metabolism is implemented in a general manner, with biotransformation possible in any compartment. Biotransformation is limited to the liver and kidney by setting the V ax coefficients for compartments other than the liver and kidney to zero (see Lines 100 and 101 in Code Listing 3, Appendix 43.3). 

Visser, D., Schmid, J. W., Mauch, K., Reuss, M. and Heijnen, J. J. (2004). Optimal redesign of primary metabolism in Escherichia coli using Unlog kinetics. Metabolic Engineering, 6(4), 378-390. 

Summary reports/NDA kinetics Metabolism (animal, human)... 

M. Moguilewsky et al, ibid. 24, 139 (1986). Kinetics, metabolism and review of clinical studies J.-p. Raynaud et al. Prog. Clin. Biol Res. 185A, 99-120 (1985), Effect on ocular response C. Hamois er al, Bril J. Ophthalmol 70, 471 (1986), Review of pharmacology, mechanism of action and effect on LHRH J.-P. Raynaud et al. Pros-fate 5, 299-311 (1984), Clinical study of combination with LHRH agonist in prostate cancer F. Labrie et al., Int. Congr. Ser.-Excerpta Med. 655, 450 (1984),, ... 

Babcock AK, Henkin RI, Aamodt RL, Foster DM and Berman M (1982) Effects of oral zinc loading on zinc metabolism in humans II In vivo kinetics. Metabolism 31 335-347. 

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