Structural kinetic modeling cellular metabolism

Thus, the kinetics of conversions In metabolic cellular sequences, and even in whole cell kinetics, at or near steady state may be expected to resemble the kinetic rate form appropriate to one or a very small number of sequential enzyme catalyzed steps. The implications of this point in kinetic models of structured cell systems are reflected in later contributions in this conference. 

Due to lack of kinetic parameters, structural metabolic network modeling has been widely applied for analyzing cellular metabolism under steady-state. Depending on what assumptions are made and whether experimental data are required, different techniques have been developed to analyze the invariant of metabohc networks such as metabolic flux analysis (MFA), flux balance analysis (FBA), and metabolic pathway analysis (MPA) including elementary mode and extreme pathway analyses (Lewis et al. 2012 Stephanopoulos et al. 1998 Trinh et al. 2(X)9). 

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