Metabolic modeling kinetic models

Jin, Q., 2007, Control of hydrogen partial pressures on the rates of syntrophic microbial metabolisms a kinetic model for butyrate fermentation. Geobiology 5, 35-48. 

These differences probably contribute to the fact that mathematical modeling is, as yet, not seen as a mainstream research tool in many areas of molecular biology. However, as will be described in the remainder of this chapter, many obstacles in the construction of kinetic models of cellular metabolism can be addressed using a combination of novel and established experimental and computational techniques, enabling the construction of metabolic models of increasing complexity and size. 

Aiming to construct explicit dynamic models, Eqs. (5) and (6) provide the basic relationships of all metabolic modeling. All current efforts to construct large-scale kinetic models are based on an specification of the elements of Eq (5), usually involving several rounds of iterative refinement For a schematic workflow, see again Fig. 4. In the following sections, we provide a brief summary of the properties of the stoichiometric matrix (Section III.B) and discuss the most common functional form of enzyme-kinetic rate equations (Section III.C). A selection of explicit kinetic models is provided in Table I. TABLE I Selected Examples of Explicit Kinetic Models of Metabolisin 1 ... 

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