Statistical analysis, protein folding kinetics

STATISTICAL ANALYSIS OF PROTEIN FOLDING KINETICS input layer hidden layer output layer... 

In Section VIII, we incorporated into the lattice model features expected due to the presence of a macromolecular chain running throu the structure. We have not yet performed a kinetic analysis for this model according to the above description of protein dmaturation kinetics. It is to be expected that the conformations of Fig. 12 provide a sufficient set on which to perform the search for the slowest step in the fastest sequence of steps. The problon of performing this search is by no means a trivial one and we have not yet attempted to solve it Also there remains the problem of what is the rate of folding of a looped chain with respect to that of a chain with two free ends. (That is, if one wishes to consider such conformations in spite of the fact that these have relatively low statistical weights, i.e. low Kf.)... 

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