Kinesins proteins associated with

Kinesins are motor proteins associated with microtubules. They power the movement of chromosomes during cell division. 

Brickley K, Smith MJ, Beck M, Stephenson FA. 2005. GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins association in vivo and in vitro with kinesin. J Biol Chem 280 14723-14732. 

Mutations in motor proteins or IFs themselves (which may alter their associations with IFAPs or motors) lead to accumulations of IFs in ALS, Charcot-Marie Tooth disease 2, and Parkinson s (Goldstein and Yang, 2000 Helfand et al., 2004). Impaired assembly and transport of NFs is a critical determinant of neurodegenerative disease. Consistent with a critical role for kinesin in vivo, mice lacking the neuronal-specific conventional kinesin heavy chain KIF5A were shown to have accumulations of NF-H, as well as NF-M and NF-L, in the cell bodies of peripheral sensory neurons. The presence of these accumulations was accompanied by a reduction in... 

Controlled transformation of the chemical energy of nucleoside triphosphates into mechanical energy is called chemomechanical transduction. In addition to the actin filaments and microtubules, the motor proteins myosin and dynein or kinesin are needed for chemomechanical transduction. Several other proteins are associated with these, including regulatory proteins that control contractile activity and enzymes involved in maintaining the supply of high-energy phosphate. 

A similar approach has been taken to prepare aryl phosphoramidates such as 99 [223], as prodmgs of SH2 domain analogs for Src/Lck inhibitors. The compounds exhibit low micromolar growth inhibition in Jurkat T cells, and undergo spontaneous hydrolysis with half-lives of approximately 30 min. The same masking groups have been applied in phosphonate 100 as a suspected SH2 domain blocker through inhibition of mitotic centromere-associated kinesin protein function in a panel of... 

Microtubules are polymers of the protein tubulin which, in vivo, are probably always associated with other proteins, the Microtubule Associated Proteins (MAPs). Microtubules are the main structural components of mitotic and meiotic spindles, and of cilia and flagella in axons and dendrites, they serve as cables along which organelles are moved by kinesin and the retrograde translocator [R.D.Vale et al. Cell 43 (1986) 623-632]. Depending on the function of the microtubules, they are associated with different... 

With regard to microtubular ultrastructure, micro filaments (5-7 run in diameter) are composed of filamentous actin. The tubule-like structures are formed by a, P-tubulin heterodimers. The wall is composed of 13 parallel protofilaments. Various microtubule-associated proteins and motor proteins (kinesin and dynein) are bound to the wall. The microtubule is a polar structure, i.e., plus and minus ends. 

Yabe,J. T.,Jung, C., Chan, W. K., and Shea, T. B. (2000). Phospho-dependent association of neurofilament proteins with kinesin in situ. Cell Motil. Cytoskeleton 45,... 

The present volume covers Muscle and Molecular Motors . The first few chapters describe the ultrastructures of striated muscles and of various muscle filaments (myosin, actin, titin), they discuss the regulation of muscle contractile activity, and they explore the mechanism of force production and movement. The book then sets out to survey other kinds of motor systems microtubules and their interactions with both microtubule associated proteins (MAPs) and the motor proteins kinesin and dynein, the major sperm protein in nematodes, the rotary ATPases driven by or driving proton gradients, and the action of motor enzymes, polymerases, on nucleic acids. The aim throughout is to explore different molecular mechanisms of motor action in order to identify common themes. 

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