Kidney tumors mortality

In 10 552 Swedish patients (mean age 57 years) who received I for hyperthyroidism (mean follow-up 15 years) there were increases in overall cancer mortality and deaths due to carcinoma of the stomach, lung, and kidney. While the findings for stomach cancer may be of significance, for tumors at other sites, because of an association with time after I treatment (58 cases at 10 years or more of follow-up against the expected 44 cases), the lack of a relation between cancer mortality and either the time from radioiodine treatment or the dose administered argues against a carcinogenic effect of radioiodine (SEDA-17, 475) (25). 

In a chronic study, weanling Sprague-Dawley rats (20 animals of each sex per exposure group) were fed (ad libitum) diets containing 0, 0.005, 0.05, 0.5, 5.0, or 50 mg kg octachlorostyrene in diet (fed ad libitum) for 12 months. While there was some mortality, it did not appear to be related to treatment. Similarly, tumor incidence was infrequent and appeared unrelated to treatment. However, 5.0 and 50 mg kg exposures resulted in kidney effects (e.g., dose-related dilation of proximal tubules and cytoplasmic eosinophilia along with granular casts and proteinaceous losses), and induction of aniline hydroxylase and aminopyrine demethylase activities in hepatic microsomes of both sexes. At the highest exposure level only (50 mg kg ), there was a... 

Systemic fungal infections are a major cause of morbidity and mortality in the immunocompromised patient. Fungal infections account for 20% to 30% of fatal infections in patients with acute leukemia, 10% to 15% of fatal infections in patients with lymphoma, and 5% of fatal infections in patients with solid tumors. The frequency of fungal infections among transplant recipients ranges from 0% to 20% for kidney and bone marrow transplant recipients to 10% to 35% for heart transplant recipients and 30% to 40% for liver transplant recipients. ... 

In rats fed diets containing 0, 400, 800, or 2000 ppm (0, 0.04, 0.08, or 0.2%) P-asarone for 2 years, none of the animals receiving 2000 ppm P-asarone survived more than 84 weeks, and mortality was increased at the 800 ppm dose. Gross pathological changes were observed and included serous fluid in the abdominal and pleural cavities, liver and kidney changes, and tumorous masses in the intestinal tract. Occurrence of tumors was dose-related. Ghanges in... 

In rats provided with coffee at dilutions of 25,50, or 100% (intake at the 100% level was equivalent to human intake of 37 cups coffee by male rats and 67 cups coffee by female rats) as the sole source of fluid for up to 2 years, elevated levels of cholesterol were observed. A decrease in bone calcium and increase in serum calcium was observed after 1 year but returned to normal without change in treatment. Mean serum alkaline phosphatase, bilirubin, and blood urea nitrogen values were occasionally elevated. Treatment-related increases in relative weights of lungs, kidneys, liver, and epididymides were recorded. An increase in mortality was observed in females receiving 50 or 100% coffee. Levels of tumors were comparable in treatment and control groups (Palm et al. 1984). 

---