Kidney proximal convoluted tubule

Some deaths. Intranuclear inclusion bodies in cells of kidney proximal convoluted tubules... 

Renal 1.9 3.9 (yellow protein in tubule lumen eosinophilic droplets in cells of proximal convoluted tubules increased kidney weights) 23.4 M (proteinuria) ... 

Dietary route, 11 species, diagnosed as lead poisoned All had inclusions in proximal convoluted tubules of kidney liver lead residues ranged from 3.1 to 15 mg/kg fresh weight 12... 

Suramin is not absorbed from the intestinal tract and is administered intravenously. Although the initial high plasma levels drop rapidly, suramin binds tightly to and is slowly released from plasma proteins, and so it persists in the host for up to 3 months. Suramin neither penetrates red blood cells nor enters the CNS. It is taken up by the reticuloendothelial cells and accumulates in the Kupffer cells of the liver and in the epithelial cells of the proximal convoluted tubules of the kidney. It is excreted by glomerular filtration, largely as the intact molecule. 

At least seven different systems are known for transporting amino acids into cells. In the inherited disorder cystinuria, the carrier system responsible for reabsorption of the amino acids cysteine, ornithine, arginine, and lysine in the proximal convoluted tubule of the kidney is defective. The inability to reabsorb cystine leads to kidney stones. 

Renal changes have been evaluated following chronic oral exposure of rats and mice to stannous chloride. The studies involved here have been described under Hepatic Effects. Vacuolar changes in the proximal convoluted tubules of the kidney were significantly increased in rats administered stannous chloride as compared with controls (Schroeder et al. 1968). However, in 14 day, 13 week, and 105 week studies of stannous chloride in rats and mice, no treatment-related nonneoplastic renal changes were reported (NTP 1982). 

McDowell, E.M. (1972). Light- and electron-microscope studies of the rat kidney after administration of inhibitors of the citric acid cycle in vivo changes in the proximal convoluted tubule during fluorocitrate poisoning. Pathology 108 303-18. 

OH D3 is further hydroxylated at 1-position by a specific 25-OH-cholecalciferol 1-hydroxylase enz5une, primarily present in the proximal convoluted tubules of kidney, forming 1,25-dihydroxy cholecalciferol (DHCC) with the help of cytochromP-450, molecular oxygen NADPH. 1,25-dihydroxycholecalciferol, or active Vitamin D, contains three hydroxyl groups at 1, 3 and 25 positions. So it is called calcitriol and it is biologically active form of vitamin D. 

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